Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes

Possible chemoprotective effects of the naturally occurring alkaloid boldine, a major alkaloid of boldo (Peumus boldus Mol.) leaves and bark, including in vitro modulations of drug-metabolizing enzymes in mouse hepatoma Hepa-1 cell line and mouse hepatic microsomes, were investigated. Boldine manife...

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Veröffentlicht in:	Pharmazie 2001-03, Vol.56 (3), p.242-243
Hauptverfasser:	KUBINOVA, R, MACHALA, M, MINKSOVA, K, NECA, J, SUCHY, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Aporphines - pharmacology Biological and medical sciences Brazil Carcinogenesis, carcinogens and anticarcinogens Cell Line Chemical agents Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 Enzyme System - metabolism Glutathione Transferase - metabolism In Vitro Techniques Medical sciences Mice Mice, Inbred C57BL Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Pharmaceutical Preparations - metabolism Plants, Medicinal - chemistry Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
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