Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men
Divisions of 1 Endocrinology and Metabolism and 2 Gerontology and Geriatrics, Departments of Medicine, Johns Hopkins Bayview Medical Center and Johns Hopkins University School of Medicine and 3 Endocrinology Section, Laboratory of Clinical Investigation, Intramural Research Program, National Inst...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2001-04, Vol.280 (4), p.E616-E625 |
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| creator | Gusenoff, Jeffrey A Harman, S. Mitchell Veldhuis, Johannes D Jayme, Jocelyn J St. Clair, Carol Munzer, Thomas Christmas, Colleen O'Connor, Kieran G Stevens, Thomas E Bellantoni, Michele F Pabst, Katherine Blackman, Marc R |
| description | Divisions of 1 Endocrinology and Metabolism and
2 Gerontology and Geriatrics, Departments of Medicine, Johns
Hopkins Bayview Medical Center and Johns Hopkins University School of
Medicine and 3 Endocrinology Section, Laboratory of Clinical
Investigation, Intramural Research Program, National Institute on
Aging, National Institutes of Health, Baltimore, Maryland 21224; and
4 Division of Endocrinology and Metabolism, Department of
Medicine, University of Virginia Health System, Charlottesville,
Virginia 22908
We studied 130 healthy aged women
( n = 57) and men ( n = 73), age
65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these
relationships differ by sex. Blood was sampled every 20 min from 8:00
PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric
assay, followed by deconvolution analyses of hormone secretory
parameters and assessment of approximate entropy (ApEn) and cross-ApEn.
Cortisol mass/burst, cortisol production rate, and mean and integrated
serum cortisol concentrations ( P |
| doi_str_mv | 10.1152/ajpendo.2001.280.4.E616 |
| format | Article |
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2 Gerontology and Geriatrics, Departments of Medicine, Johns
Hopkins Bayview Medical Center and Johns Hopkins University School of
Medicine and 3 Endocrinology Section, Laboratory of Clinical
Investigation, Intramural Research Program, National Institute on
Aging, National Institutes of Health, Baltimore, Maryland 21224; and
4 Division of Endocrinology and Metabolism, Department of
Medicine, University of Virginia Health System, Charlottesville,
Virginia 22908
We studied 130 healthy aged women
( n = 57) and men ( n = 73), age
65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these
relationships differ by sex. Blood was sampled every 20 min from 8:00
PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric
assay, followed by deconvolution analyses of hormone secretory
parameters and assessment of approximate entropy (ApEn) and cross-ApEn.
Cortisol mass/burst, cortisol production rate, and mean and integrated
serum cortisol concentrations ( P < 0.0005), and
overnight basal GH secretion ( P < 0.05), were elevated in women vs. men. Integrated cortisol concentrations were directly related to most measures of GH secretion in women ( P < 0.01) and with mean and integrated GH concentrations in men
( P < 0.05). Integrated GH concentrations were directly
related to mean and integrated cortisol levels in women ( P < 0.005) and men ( P < 0.05), with no sex
differences. There were no sex differences in cortisol or GH ApEn
values; however, the cross-ApEn score was greater in women
( P < 0.05), indicating reduced GH-cortisol pattern
synchrony in aged women vs. men. There were no significant
relationships of integrated cortisol secretion with GH ApEn, or vice
versa, in either sex. Thus postmenopausal women appear to maintain
elevated cortisol production in patterns that are relatively uncoupled from those of GH, whereas mean hormone outputs remain correlated.
aging; hormone secretion; approximate entropy]]></description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.2001.280.4.E616</identifier><identifier>PMID: 11254469</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Aged, 80 and over ; Aging - metabolism ; Body Composition ; Body Mass Index ; Female ; Human Growth Hormone - secretion ; Humans ; Hydrocortisone - secretion ; Male ; Multivariate Analysis ; Reference Values ; Regression Analysis</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2001-04, Vol.280 (4), p.E616-E625</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-85a54b0f8ad7a3e1d367351d73479b8afe2a97c00544ee6c52ae52051d40cfbd3</citedby><cites>FETCH-LOGICAL-c397t-85a54b0f8ad7a3e1d367351d73479b8afe2a97c00544ee6c52ae52051d40cfbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11254469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gusenoff, Jeffrey A</creatorcontrib><creatorcontrib>Harman, S. Mitchell</creatorcontrib><creatorcontrib>Veldhuis, Johannes D</creatorcontrib><creatorcontrib>Jayme, Jocelyn J</creatorcontrib><creatorcontrib>St. Clair, Carol</creatorcontrib><creatorcontrib>Munzer, Thomas</creatorcontrib><creatorcontrib>Christmas, Colleen</creatorcontrib><creatorcontrib>O'Connor, Kieran G</creatorcontrib><creatorcontrib>Stevens, Thomas E</creatorcontrib><creatorcontrib>Bellantoni, Michele F</creatorcontrib><creatorcontrib>Pabst, Katherine</creatorcontrib><creatorcontrib>Blackman, Marc R</creatorcontrib><title>Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description><![CDATA[Divisions of 1 Endocrinology and Metabolism and
2 Gerontology and Geriatrics, Departments of Medicine, Johns
Hopkins Bayview Medical Center and Johns Hopkins University School of
Medicine and 3 Endocrinology Section, Laboratory of Clinical
Investigation, Intramural Research Program, National Institute on
Aging, National Institutes of Health, Baltimore, Maryland 21224; and
4 Division of Endocrinology and Metabolism, Department of
Medicine, University of Virginia Health System, Charlottesville,
Virginia 22908
We studied 130 healthy aged women
( n = 57) and men ( n = 73), age
65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these
relationships differ by sex. Blood was sampled every 20 min from 8:00
PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric
assay, followed by deconvolution analyses of hormone secretory
parameters and assessment of approximate entropy (ApEn) and cross-ApEn.
Cortisol mass/burst, cortisol production rate, and mean and integrated
serum cortisol concentrations ( P < 0.0005), and
overnight basal GH secretion ( P < 0.05), were elevated in women vs. men. Integrated cortisol concentrations were directly related to most measures of GH secretion in women ( P < 0.01) and with mean and integrated GH concentrations in men
( P < 0.05). Integrated GH concentrations were directly
related to mean and integrated cortisol levels in women ( P < 0.005) and men ( P < 0.05), with no sex
differences. There were no sex differences in cortisol or GH ApEn
values; however, the cross-ApEn score was greater in women
( P < 0.05), indicating reduced GH-cortisol pattern
synchrony in aged women vs. men. There were no significant
relationships of integrated cortisol secretion with GH ApEn, or vice
versa, in either sex. Thus postmenopausal women appear to maintain
elevated cortisol production in patterns that are relatively uncoupled from those of GH, whereas mean hormone outputs remain correlated.
aging; hormone secretion; approximate entropy]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Human Growth Hormone - secretion</subject><subject>Humans</subject><subject>Hydrocortisone - secretion</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv2yAYhtG0as3a_oXNp51mDzAYc5yitJ1UaZf2jIj5HFNh4wFR638_0mRKLzt9h_d9XtCD0FeCK0I4_aGfZ5iMryjGpKItrli1aUjzAa1ySkvCOf-IVpjIuiQtk5foc4zPGGPBGf2ELgmhnLFGrpBa-5Bs9K7Qkynu7osIXYDkw1KYZdKj7eL3tygNYENhpwQhgNPJ-ikOds6pnYoBtEvDUugdmOLFjzC9Mfleo4teuwg3p3uFnm43j-v78uH33a_1z4eyq6VIZcs1Z1vct9oIXQMxdSNqToyomZDbVvdAtRQdxvnbAE3HqQZOcW4w3PVbU1-hb8fdOfg_e4hJjTZ24JyewO-jEo1ssyeZi-JY7IKPMUCv5mBHHRZFsDq4VSe36uBWZUYxdXCbyS-nJ_bbEcyZO8nMhfJYGOxueLEB1Dws0Xrnd8t59f2g_H__du_cI7ymf-CZU7Pp679SRp10</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Gusenoff, Jeffrey A</creator><creator>Harman, S. Mitchell</creator><creator>Veldhuis, Johannes D</creator><creator>Jayme, Jocelyn J</creator><creator>St. Clair, Carol</creator><creator>Munzer, Thomas</creator><creator>Christmas, Colleen</creator><creator>O'Connor, Kieran G</creator><creator>Stevens, Thomas E</creator><creator>Bellantoni, Michele F</creator><creator>Pabst, Katherine</creator><creator>Blackman, Marc R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men</title><author>Gusenoff, Jeffrey A ; Harman, S. Mitchell ; Veldhuis, Johannes D ; Jayme, Jocelyn J ; St. Clair, Carol ; Munzer, Thomas ; Christmas, Colleen ; O'Connor, Kieran G ; Stevens, Thomas E ; Bellantoni, Michele F ; Pabst, Katherine ; Blackman, Marc R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-85a54b0f8ad7a3e1d367351d73479b8afe2a97c00544ee6c52ae52051d40cfbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Human Growth Hormone - secretion</topic><topic>Humans</topic><topic>Hydrocortisone - secretion</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gusenoff, Jeffrey A</creatorcontrib><creatorcontrib>Harman, S. Mitchell</creatorcontrib><creatorcontrib>Veldhuis, Johannes D</creatorcontrib><creatorcontrib>Jayme, Jocelyn J</creatorcontrib><creatorcontrib>St. Clair, Carol</creatorcontrib><creatorcontrib>Munzer, Thomas</creatorcontrib><creatorcontrib>Christmas, Colleen</creatorcontrib><creatorcontrib>O'Connor, Kieran G</creatorcontrib><creatorcontrib>Stevens, Thomas E</creatorcontrib><creatorcontrib>Bellantoni, Michele F</creatorcontrib><creatorcontrib>Pabst, Katherine</creatorcontrib><creatorcontrib>Blackman, Marc R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gusenoff, Jeffrey A</au><au>Harman, S. Mitchell</au><au>Veldhuis, Johannes D</au><au>Jayme, Jocelyn J</au><au>St. Clair, Carol</au><au>Munzer, Thomas</au><au>Christmas, Colleen</au><au>O'Connor, Kieran G</au><au>Stevens, Thomas E</au><au>Bellantoni, Michele F</au><au>Pabst, Katherine</au><au>Blackman, Marc R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>280</volume><issue>4</issue><spage>E616</spage><epage>E625</epage><pages>E616-E625</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><abstract><![CDATA[Divisions of 1 Endocrinology and Metabolism and
2 Gerontology and Geriatrics, Departments of Medicine, Johns
Hopkins Bayview Medical Center and Johns Hopkins University School of
Medicine and 3 Endocrinology Section, Laboratory of Clinical
Investigation, Intramural Research Program, National Institute on
Aging, National Institutes of Health, Baltimore, Maryland 21224; and
4 Division of Endocrinology and Metabolism, Department of
Medicine, University of Virginia Health System, Charlottesville,
Virginia 22908
We studied 130 healthy aged women
( n = 57) and men ( n = 73), age
65-88 yr, with age-related reductions in insulin-like growth factor I and gonadal steroid levels to assess the interrelationships between cortisol and growth hormone (GH) secretion and whether these
relationships differ by sex. Blood was sampled every 20 min from 8:00
PM to 8:00 AM; cortisol was measured by RIA and GH by immunoradiometric
assay, followed by deconvolution analyses of hormone secretory
parameters and assessment of approximate entropy (ApEn) and cross-ApEn.
Cortisol mass/burst, cortisol production rate, and mean and integrated
serum cortisol concentrations ( P < 0.0005), and
overnight basal GH secretion ( P < 0.05), were elevated in women vs. men. Integrated cortisol concentrations were directly related to most measures of GH secretion in women ( P < 0.01) and with mean and integrated GH concentrations in men
( P < 0.05). Integrated GH concentrations were directly
related to mean and integrated cortisol levels in women ( P < 0.005) and men ( P < 0.05), with no sex
differences. There were no sex differences in cortisol or GH ApEn
values; however, the cross-ApEn score was greater in women
( P < 0.05), indicating reduced GH-cortisol pattern
synchrony in aged women vs. men. There were no significant
relationships of integrated cortisol secretion with GH ApEn, or vice
versa, in either sex. Thus postmenopausal women appear to maintain
elevated cortisol production in patterns that are relatively uncoupled from those of GH, whereas mean hormone outputs remain correlated.
aging; hormone secretion; approximate entropy]]></abstract><cop>United States</cop><pmid>11254469</pmid><doi>10.1152/ajpendo.2001.280.4.E616</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 2001-04, Vol.280 (4), p.E616-E625 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_pubmed_primary_11254469 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Aging - metabolism Body Composition Body Mass Index Female Human Growth Hormone - secretion Humans Hydrocortisone - secretion Male Multivariate Analysis Reference Values Regression Analysis |
| title | Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men |
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