Positioning of the carboxamide side chain in 11-oxo-11H-indeno[1,2-b]quinolinecarboxamide anticancer agents : Effects on cytotoxicity

A series of 11-oxo-11H-indeno[1,2-b]quinolines bearing a carboxamide-linked cationic side chain at various positions on the chromophore was studied to determine structure-activity relationships between cytotoxicity and the position of the side chain. The compounds were prepared by Pfitzinger synthes...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2001-02, Vol.9 (2), p.445-452
Hauptverfasser:	DEADY, Leslie W, DESNEVES, José, KAYE, Anthony J, FINLAY, Graeme J, BAGULEY, Bruce C, DENNY, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Lewis Lung - pathology Cell Division - drug effects Chemotherapy Colonic Neoplasms - drug therapy Combinatorial Chemistry Techniques Humans Indenes - chemical synthesis Indenes - pharmacology Inhibitory Concentration 50 Leukemia - pathology Medical sciences Mice Neoplasm Transplantation Pharmacology. Drug treatments Quinolines - chemical synthesis Quinolines - pharmacology Structure-Activity Relationship Tumor Cells, Cultured - drug effects
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