TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis
The metanephric kidney develops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to form the epithelia of the nephron. We have found that leukemia inhibitory factor (LIF) and transforming growth factor beta 2 (TGF beta 2) are secr...
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| Veröffentlicht in: | Development (Cambridge) 2001-04, Vol.128 (7), p.1045 |
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| creator | Plisov, S Y Yoshino, K Dove, L F Higinbotham, K G Rubin, J S Perantoni, A O |
| description | The metanephric kidney develops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to form the epithelia of the nephron. We have found that leukemia inhibitory factor (LIF) and transforming growth factor beta 2 (TGF beta 2) are secreted by inductive rat bud cells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mesenchymal explants. LIF alone or TGF beta 2 with fibroblast growth factor 2 induced numerous tubules in isolated mesenchymes over an 8 day period, while (in combination) all three caused abundant tubule formation in 72 hours. Furthermore, neutralization of Wnt ligands with antagonist-secreted Frizzled-related protein 1 abrogated these responses and combinatorial cytokine/growth factor stimulation of explants augmented nuclear activation of Tcf1/Lef1, suggesting that LIF and TGF beta 2/FGF2 cooperate to regulate nephrogenesis through a common Wnt-dependent mechanism. |
| format | Article |
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Furthermore, neutralization of Wnt ligands with antagonist-secreted Frizzled-related protein 1 abrogated these responses and combinatorial cytokine/growth factor stimulation of explants augmented nuclear activation of Tcf1/Lef1, suggesting that LIF and TGF beta 2/FGF2 cooperate to regulate nephrogenesis through a common Wnt-dependent mechanism.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>PMID: 11245570</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Activin Receptors, Type I ; Animals ; Biomarkers ; Culture Media, Conditioned ; Fibroblast Growth Factor 2 - genetics ; Fibroblast Growth Factor 2 - metabolism ; Growth Inhibitors - genetics ; Growth Inhibitors - metabolism ; Interleukin-6 ; Leukemia Inhibitory Factor ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Ligands ; Lymphokines - genetics ; Lymphokines - metabolism ; Nephrons - physiology ; Protein Serine-Threonine Kinases - genetics ; Proto-Oncogene Proteins - metabolism ; Rats ; Receptor, Transforming Growth Factor-beta Type I ; Receptor, Transforming Growth Factor-beta Type II ; Receptors, Cytokine - genetics ; Receptors, OSM-LIF ; Receptors, Transforming Growth Factor beta - genetics ; Time Factors ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism ; Transforming Growth Factor beta2 ; Wnt Proteins ; Wnt4 Protein</subject><ispartof>Development (Cambridge), 2001-04, Vol.128 (7), p.1045</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11245570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plisov, S Y</creatorcontrib><creatorcontrib>Yoshino, K</creatorcontrib><creatorcontrib>Dove, L F</creatorcontrib><creatorcontrib>Higinbotham, K G</creatorcontrib><creatorcontrib>Rubin, J S</creatorcontrib><creatorcontrib>Perantoni, A O</creatorcontrib><title>TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The metanephric kidney develops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to form the epithelia of the nephron. We have found that leukemia inhibitory factor (LIF) and transforming growth factor beta 2 (TGF beta 2) are secreted by inductive rat bud cells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mesenchymal explants. LIF alone or TGF beta 2 with fibroblast growth factor 2 induced numerous tubules in isolated mesenchymes over an 8 day period, while (in combination) all three caused abundant tubule formation in 72 hours. Furthermore, neutralization of Wnt ligands with antagonist-secreted Frizzled-related protein 1 abrogated these responses and combinatorial cytokine/growth factor stimulation of explants augmented nuclear activation of Tcf1/Lef1, suggesting that LIF and TGF beta 2/FGF2 cooperate to regulate nephrogenesis through a common Wnt-dependent mechanism.</description><subject>Activin Receptors, Type I</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Culture Media, Conditioned</subject><subject>Fibroblast Growth Factor 2 - genetics</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Growth Inhibitors - genetics</subject><subject>Growth Inhibitors - metabolism</subject><subject>Interleukin-6</subject><subject>Leukemia Inhibitory Factor</subject><subject>Leukemia Inhibitory Factor Receptor alpha Subunit</subject><subject>Ligands</subject><subject>Lymphokines - genetics</subject><subject>Lymphokines - metabolism</subject><subject>Nephrons - physiology</subject><subject>Protein Serine-Threonine Kinases - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Rats</subject><subject>Receptor, Transforming Growth Factor-beta Type I</subject><subject>Receptor, Transforming Growth Factor-beta Type II</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, OSM-LIF</subject><subject>Receptors, Transforming Growth Factor beta - genetics</subject><subject>Time Factors</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Transforming Growth Factor beta2</subject><subject>Wnt Proteins</subject><subject>Wnt4 Protein</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j9FKwzAYhYMobk5fQfIAFvKnSdN4J8POQcGbeR2S5m8b6ZrSdIpv72B6deDw8XHOFVmDUCrTwPU1WTMtWQZaw4rcpfTJGMsLpW7JCoALKRVbk-fDrqIOF0v5E633FbWjp9Wu4rSJccLZLkiXSMPoTw3SEad-jh2OmEK6JzetHRI-_OWGfFSvh-1bVr_v9tuXOutBqSUrS9UK3kDLtCp16RrpLTQ6L1VjBePe5YVvwcqcu3OPBZ63oygAJFonsMg35PHinU7uiN5Mczja-cf8nzgD2QXoQ9d_hxmNC3GIXUhLMh6_cIiTAV4aZYAJmf8ChMhRxQ</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Plisov, S Y</creator><creator>Yoshino, K</creator><creator>Dove, L F</creator><creator>Higinbotham, K G</creator><creator>Rubin, J S</creator><creator>Perantoni, A O</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20010401</creationdate><title>TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis</title><author>Plisov, S Y ; Yoshino, K ; Dove, L F ; Higinbotham, K G ; Rubin, J S ; Perantoni, A O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h177t-887f42c1f097898bc5da1c9387ca402db36df1a532ba1ce6e129e46115eab4e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Activin Receptors, Type I</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Culture Media, Conditioned</topic><topic>Fibroblast Growth Factor 2 - genetics</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Growth Inhibitors - genetics</topic><topic>Growth Inhibitors - metabolism</topic><topic>Interleukin-6</topic><topic>Leukemia Inhibitory Factor</topic><topic>Leukemia Inhibitory Factor Receptor alpha Subunit</topic><topic>Ligands</topic><topic>Lymphokines - genetics</topic><topic>Lymphokines - metabolism</topic><topic>Nephrons - physiology</topic><topic>Protein Serine-Threonine Kinases - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Rats</topic><topic>Receptor, Transforming Growth Factor-beta Type I</topic><topic>Receptor, Transforming Growth Factor-beta Type II</topic><topic>Receptors, Cytokine - genetics</topic><topic>Receptors, OSM-LIF</topic><topic>Receptors, Transforming Growth Factor beta - genetics</topic><topic>Time Factors</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Transforming Growth Factor beta2</topic><topic>Wnt Proteins</topic><topic>Wnt4 Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plisov, S Y</creatorcontrib><creatorcontrib>Yoshino, K</creatorcontrib><creatorcontrib>Dove, L F</creatorcontrib><creatorcontrib>Higinbotham, K G</creatorcontrib><creatorcontrib>Rubin, J S</creatorcontrib><creatorcontrib>Perantoni, A O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plisov, S Y</au><au>Yoshino, K</au><au>Dove, L F</au><au>Higinbotham, K G</au><au>Rubin, J S</au><au>Perantoni, A O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>128</volume><issue>7</issue><spage>1045</spage><pages>1045-</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The metanephric kidney develops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to form the epithelia of the nephron. We have found that leukemia inhibitory factor (LIF) and transforming growth factor beta 2 (TGF beta 2) are secreted by inductive rat bud cells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mesenchymal explants. LIF alone or TGF beta 2 with fibroblast growth factor 2 induced numerous tubules in isolated mesenchymes over an 8 day period, while (in combination) all three caused abundant tubule formation in 72 hours. Furthermore, neutralization of Wnt ligands with antagonist-secreted Frizzled-related protein 1 abrogated these responses and combinatorial cytokine/growth factor stimulation of explants augmented nuclear activation of Tcf1/Lef1, suggesting that LIF and TGF beta 2/FGF2 cooperate to regulate nephrogenesis through a common Wnt-dependent mechanism.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>11245570</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2001-04, Vol.128 (7), p.1045 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_pubmed_primary_11245570 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Activin Receptors, Type I Animals Biomarkers Culture Media, Conditioned Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Growth Inhibitors - genetics Growth Inhibitors - metabolism Interleukin-6 Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Ligands Lymphokines - genetics Lymphokines - metabolism Nephrons - physiology Protein Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - metabolism Rats Receptor, Transforming Growth Factor-beta Type I Receptor, Transforming Growth Factor-beta Type II Receptors, Cytokine - genetics Receptors, OSM-LIF Receptors, Transforming Growth Factor beta - genetics Time Factors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta2 Wnt Proteins Wnt4 Protein |
| title | TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis |
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