Experimental Manipulation of Preleukemic Change in Whole-Body Irradiated RFM/Up Mice
Summary Radiation which induces leu-kemogenesis in the unirradiated mouse, inhibits leukemogenesis if given again to the previously irradiated, but not yet leukemic mouse. The objective of this experiment was to identify nonmalignant late radiation injury in the bone marrow, the modification of whic...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1975-02, Vol.148 (2), p.375-379 |
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| container_issue | 2 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 148 |
| creator | Ludwig, F. C. Morat, M. M. Schug, W. G. |
| description | Summary
Radiation which induces leu-kemogenesis in the unirradiated mouse, inhibits leukemogenesis if given again to the previously irradiated, but not yet leukemic mouse. The objective of this experiment was to identify nonmalignant late radiation injury in the bone marrow, the modification of which by a second exposure may account for postponement of radiogenic leukemia. To this end, leukemogenically irradiated RFM/ Up mice were reirradiated under conditions known to bring about postponement of the leukemias due to the first radiation exposure. Quantitative analysis of the femoral bone marrow of these mice shows that leukemia incidence is positively correlated with the number of immature myeloid cells, and negatively correlated with the percentage of the mature myeloid cells in the entire myeloid series. The implications of this for the understanding of preleukemic change are discussed. |
| doi_str_mv | 10.3181/00379727-148-38542 |
| format | Article |
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Radiation which induces leu-kemogenesis in the unirradiated mouse, inhibits leukemogenesis if given again to the previously irradiated, but not yet leukemic mouse. The objective of this experiment was to identify nonmalignant late radiation injury in the bone marrow, the modification of which by a second exposure may account for postponement of radiogenic leukemia. To this end, leukemogenically irradiated RFM/ Up mice were reirradiated under conditions known to bring about postponement of the leukemias due to the first radiation exposure. Quantitative analysis of the femoral bone marrow of these mice shows that leukemia incidence is positively correlated with the number of immature myeloid cells, and negatively correlated with the percentage of the mature myeloid cells in the entire myeloid series. The implications of this for the understanding of preleukemic change are discussed.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-148-38542</identifier><identifier>PMID: 1121485</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Bone Marrow - radiation effects ; Bone Marrow Cells ; BONE MARROW- DELAYED RADIATION EFFECTS ; Leukemia, Experimental ; Leukemia, Radiation-Induced ; LEUKEMOGENESIS- RADIOINDUCTION ; Male ; MICE ; Models, Biological ; N48520 -Life Sciences-Radiation Effects on Animals- Vertebrates ; Precancerous Conditions ; Radiation Dosage ; Radiation Effects ; WHOLE-BODY IRRADIATION ; X RADIATION</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1975-02, Vol.148 (2), p.375-379</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-dad9ca49f9dab16a0c8c4dd3b40be9fcfcdabedc6622350d49b67ba7929368943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1121485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4205375$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ludwig, F. C.</creatorcontrib><creatorcontrib>Morat, M. M.</creatorcontrib><creatorcontrib>Schug, W. G.</creatorcontrib><creatorcontrib>Univ. of California, Irvine</creatorcontrib><title>Experimental Manipulation of Preleukemic Change in Whole-Body Irradiated RFM/Up Mice</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Radiation which induces leu-kemogenesis in the unirradiated mouse, inhibits leukemogenesis if given again to the previously irradiated, but not yet leukemic mouse. The objective of this experiment was to identify nonmalignant late radiation injury in the bone marrow, the modification of which by a second exposure may account for postponement of radiogenic leukemia. To this end, leukemogenically irradiated RFM/ Up mice were reirradiated under conditions known to bring about postponement of the leukemias due to the first radiation exposure. Quantitative analysis of the femoral bone marrow of these mice shows that leukemia incidence is positively correlated with the number of immature myeloid cells, and negatively correlated with the percentage of the mature myeloid cells in the entire myeloid series. The implications of this for the understanding of preleukemic change are discussed.</description><subject>Animals</subject><subject>Bone Marrow - radiation effects</subject><subject>Bone Marrow Cells</subject><subject>BONE MARROW- DELAYED RADIATION EFFECTS</subject><subject>Leukemia, Experimental</subject><subject>Leukemia, Radiation-Induced</subject><subject>LEUKEMOGENESIS- RADIOINDUCTION</subject><subject>Male</subject><subject>MICE</subject><subject>Models, Biological</subject><subject>N48520 -Life Sciences-Radiation Effects on Animals- Vertebrates</subject><subject>Precancerous Conditions</subject><subject>Radiation Dosage</subject><subject>Radiation Effects</subject><subject>WHOLE-BODY IRRADIATION</subject><subject>X RADIATION</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gCAE7-Py0bTNpY5NhQ1FNrwMaXK6ZXZtaTtw_97MKt55deC8H_A-CF0zeidYysaUikQlPCEsSolIZcRP0JBJIYmIlTpFw6OBHB3n6KJtt5QymfB4gAaM8ZCRQ7ScftbQ-B2UnSnwwpS-3hem81WJqxy_NlDA_gN23uLJxpRrwL7E75uqAPJQuQN-bhrjvOnA4bfZYryq8cJbuERnuSlauPq5I7SaTZeTJzJ_eXye3M-JFbHsiDNOWROpXDmTsdhQm9rIOZFFNAOV29yGPzgbx5wLSV2ksjjJTKK4EnGqIjFCt31v1XZet9Z3YDe2KkuwnY44lSKRwcR7k22qtm0g13XYa5qDZlQfMepfjDog0d8YQ-imD9X7bAfuL9JzC_q411uzBr2t9k0Zhv7X-AUsA3s5</recordid><startdate>197502</startdate><enddate>197502</enddate><creator>Ludwig, F. C.</creator><creator>Morat, M. M.</creator><creator>Schug, W. G.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>197502</creationdate><title>Experimental Manipulation of Preleukemic Change in Whole-Body Irradiated RFM/Up Mice</title><author>Ludwig, F. C. ; Morat, M. M. ; Schug, W. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-dad9ca49f9dab16a0c8c4dd3b40be9fcfcdabedc6622350d49b67ba7929368943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Bone Marrow - radiation effects</topic><topic>Bone Marrow Cells</topic><topic>BONE MARROW- DELAYED RADIATION EFFECTS</topic><topic>Leukemia, Experimental</topic><topic>Leukemia, Radiation-Induced</topic><topic>LEUKEMOGENESIS- RADIOINDUCTION</topic><topic>Male</topic><topic>MICE</topic><topic>Models, Biological</topic><topic>N48520 -Life Sciences-Radiation Effects on Animals- Vertebrates</topic><topic>Precancerous Conditions</topic><topic>Radiation Dosage</topic><topic>Radiation Effects</topic><topic>WHOLE-BODY IRRADIATION</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ludwig, F. C.</creatorcontrib><creatorcontrib>Morat, M. M.</creatorcontrib><creatorcontrib>Schug, W. G.</creatorcontrib><creatorcontrib>Univ. of California, Irvine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ludwig, F. C.</au><au>Morat, M. M.</au><au>Schug, W. G.</au><aucorp>Univ. of California, Irvine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Manipulation of Preleukemic Change in Whole-Body Irradiated RFM/Up Mice</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1975-02</date><risdate>1975</risdate><volume>148</volume><issue>2</issue><spage>375</spage><epage>379</epage><pages>375-379</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Radiation which induces leu-kemogenesis in the unirradiated mouse, inhibits leukemogenesis if given again to the previously irradiated, but not yet leukemic mouse. The objective of this experiment was to identify nonmalignant late radiation injury in the bone marrow, the modification of which by a second exposure may account for postponement of radiogenic leukemia. To this end, leukemogenically irradiated RFM/ Up mice were reirradiated under conditions known to bring about postponement of the leukemias due to the first radiation exposure. Quantitative analysis of the femoral bone marrow of these mice shows that leukemia incidence is positively correlated with the number of immature myeloid cells, and negatively correlated with the percentage of the mature myeloid cells in the entire myeloid series. The implications of this for the understanding of preleukemic change are discussed.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>1121485</pmid><doi>10.3181/00379727-148-38542</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1975-02, Vol.148 (2), p.375-379 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_1121485 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Bone Marrow - radiation effects Bone Marrow Cells BONE MARROW- DELAYED RADIATION EFFECTS Leukemia, Experimental Leukemia, Radiation-Induced LEUKEMOGENESIS- RADIOINDUCTION Male MICE Models, Biological N48520 -Life Sciences-Radiation Effects on Animals- Vertebrates Precancerous Conditions Radiation Dosage Radiation Effects WHOLE-BODY IRRADIATION X RADIATION |
| title | Experimental Manipulation of Preleukemic Change in Whole-Body Irradiated RFM/Up Mice |
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