Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional regulator of several genes including the cytochrome P4501 (CYP1) family as well as genes encoding factors involved in cell growth and differentiation. In mice, several polymorphic forms of the AHR are known, some of which have...

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Veröffentlicht in:	Pharmacogenetics (London) 2001-02, Vol.11 (1), p.85-94
Hauptverfasser:	WONG, Judy M. Y, HARPER, Patricia A, OKEY, Allan B, MEYER, Urs A, BOCK, Karl Walter, MÖRIKE, Klaus, LAGUEUX, Jean, AYOTTE, Pierre, TYNDALE, Rachel F, SELLERS, Edward M, MANCHESTER, David K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arginine - genetics Biological and medical sciences Codon - genetics Electrophoresis, Polyacrylamide Gel Ethnic Groups - genetics Female Gene Frequency - genetics General pharmacology Genetic Variation - genetics Humans Lysine - genetics Medical sciences Pedigree Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymerase Chain Reaction - methods Polymorphism, Single-Stranded Conformational Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - physiology Tumor Cells, Cultured
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