Comparison of Glycyrrhetinic Acid Isoforms and Carbenoxolone as Inhibitors of EDHF-Type Relaxations Mediated via Gap Junctions

The vascular actions of the lipophilic gap junction inhibitors 18α-glycyrrhetinic acid (18α-GA), 18β-glycyrrhetinic acid (18β-GA) and the water-soluble hemisuccinate derivative of 18β-GA, carbenoxolone, were investigated in preconstricted rings of rabbit superior mesenteric artery. EDHF-type relaxat...

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Veröffentlicht in:	Endothelium (New York, N.Y.) N.Y.), 2000, Vol.7 (4), p.265-278
Hauptverfasser:	Chaytor, Andrew T., Marsh, Wendy L., Hutcheson, Iain R., Griffith, Tudor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	18α-glycyrrhetinic acid 18β-glycyrrhetinic acid acetylcholine Acetylcholine - pharmacology Animals Biological Factors - pharmacology carbenoxolone Carbenoxolone - pharmacology endothelium-derived hyperpolarizing factor (EDHF) gap junctions Gap Junctions - drug effects Gap Junctions - physiology Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology In Vitro Techniques Indomethacin - pharmacology Isomerism Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiology NG-Nitroarginine Methyl Ester - pharmacology nitric oxide Nitroprusside - pharmacology Phenylephrine - pharmacology Rabbits Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology
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