Signal Transduction in G0/G1-Arrested Mouse Y1 Adrenocortical Cells Stimulated by Acth and FGF2

In G0/G1 cell cycle arrested mouse Y1 adrenocortical tumor cells ACTH39, a weak mitogen and strong anti-mitogenic agent, blocks FGF2 mitogenic activity at G1 phase, keeping untouched ERK-MAPK activation and c-Fos protein induction. Here we report two anti-mitogenic mechanisms initiated in ACTH recep...

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Veröffentlicht in:	Endocrine research 2000, Vol.26 (4), p.825-832
Hauptverfasser:	Lepique, Ana P., Forti, Fábio L., Moraes, Miriam S., Armelin, Hugo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - drug effects Adrenal Cortex - pathology Adrenocorticotropic Hormone - pharmacology Animals Down-Regulation Fibroblast Growth Factor 2 - pharmacology G1 Phase - physiology Mice Phosphorylation - drug effects Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-myc - metabolism Resting Phase, Cell Cycle - physiology Signal Transduction - drug effects Tumor Cells, Cultured
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