Blood Pressure Control in Essential Hypertension and Impairment of Renal Function with Age
Hypertension has been recognized to be an important cause for the development of end-stage renal disease (ESRD). We assessed the quality of blood pressure control in 103 patients with essential hypertension and correlated renal function and age. Patients were stratified into three subgroups by their...
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| Veröffentlicht in: | Blood pressure 2000, Vol.9 (5), p.293-297 |
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| description | Hypertension has been recognized to be an important cause for the development of end-stage renal disease (ESRD). We assessed the quality of blood pressure control in 103 patients with essential hypertension and correlated renal function and age. Patients were stratified into three subgroups by their blood pressure level under current medication. Group 1 were hypertensive patients with normalized blood pressure (160/100 mmHg, n = 35). A negative correlation between age and creatinine clearance (CCr) could be confirmed for patients of group 1 (correlation coefficient r1 = -0.56; p1 < 0.01) and group 2 (r2 = -0.55; p2 < 0.001). Furthermore the regression coefficient (m) of decline in CCr versus age was higher in group 2 patients (m2 = -1.83) than in group 1 (m1 = -1.30). In group 3 we found no correlation of renal function with age, indicating that age may not be the leading variable. Patients in group 1 were all within normal limits of age adjusted CCr, but 12% in group 2 and 23% in group 3 had impaired CCr. Furthermore proteinuria was found to be 20% (group 1), 26% (group 2) and 31% (group 3). This analysis provides further evidence of the importance of blood pressure control in essential hypertension to preserve renal function. |
| doi_str_mv | 10.1080/080370500448696 |
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We assessed the quality of blood pressure control in 103 patients with essential hypertension and correlated renal function and age. Patients were stratified into three subgroups by their blood pressure level under current medication. Group 1 were hypertensive patients with normalized blood pressure (<140/90 mmHg, n = 25), group 2 patients with mild hypertension (140-159/90-99 mmHg, n = 43) and group 3 patients with moderate to severe hypertension (>160/100 mmHg, n = 35). A negative correlation between age and creatinine clearance (CCr) could be confirmed for patients of group 1 (correlation coefficient r1 = -0.56; p1 < 0.01) and group 2 (r2 = -0.55; p2 < 0.001). Furthermore the regression coefficient (m) of decline in CCr versus age was higher in group 2 patients (m2 = -1.83) than in group 1 (m1 = -1.30). In group 3 we found no correlation of renal function with age, indicating that age may not be the leading variable. Patients in group 1 were all within normal limits of age adjusted CCr, but 12% in group 2 and 23% in group 3 had impaired CCr. Furthermore proteinuria was found to be 20% (group 1), 26% (group 2) and 31% (group 3). This analysis provides further evidence of the importance of blood pressure control in essential hypertension to preserve renal function.</description><identifier>ISSN: 0803-7051</identifier><identifier>EISSN: 1651-1999</identifier><identifier>DOI: 10.1080/080370500448696</identifier><identifier>PMID: 11193134</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Adaptation, Physiological ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging - physiology ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Creatinine - blood ; Creatinine - urine ; Female ; Humans ; Hypertension - drug therapy ; Hypertension - metabolism ; Hypertension - physiopathology ; Kidney - physiopathology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - prevention & control ; Male ; Medical sciences ; Middle Aged ; Proteinuria - etiology</subject><ispartof>Blood pressure, 2000, Vol.9 (5), p.293-297</ispartof><rights>2000 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2000</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c417t-ae85be433c0c120b13def70039e49f3bdc42d97a56d7bf2a3cadd006048335563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/080370500448696$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/080370500448696$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=826406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11193134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MONDORF, ULRICH F.</creatorcontrib><title>Blood Pressure Control in Essential Hypertension and Impairment of Renal Function with Age</title><title>Blood pressure</title><addtitle>Blood Press</addtitle><description>Hypertension has been recognized to be an important cause for the development of end-stage renal disease (ESRD). We assessed the quality of blood pressure control in 103 patients with essential hypertension and correlated renal function and age. Patients were stratified into three subgroups by their blood pressure level under current medication. Group 1 were hypertensive patients with normalized blood pressure (<140/90 mmHg, n = 25), group 2 patients with mild hypertension (140-159/90-99 mmHg, n = 43) and group 3 patients with moderate to severe hypertension (>160/100 mmHg, n = 35). A negative correlation between age and creatinine clearance (CCr) could be confirmed for patients of group 1 (correlation coefficient r1 = -0.56; p1 < 0.01) and group 2 (r2 = -0.55; p2 < 0.001). Furthermore the regression coefficient (m) of decline in CCr versus age was higher in group 2 patients (m2 = -1.83) than in group 1 (m1 = -1.30). In group 3 we found no correlation of renal function with age, indicating that age may not be the leading variable. Patients in group 1 were all within normal limits of age adjusted CCr, but 12% in group 2 and 23% in group 3 had impaired CCr. Furthermore proteinuria was found to be 20% (group 1), 26% (group 2) and 31% (group 3). This analysis provides further evidence of the importance of blood pressure control in essential hypertension to preserve renal function.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Proteinuria - etiology</subject><issn>0803-7051</issn><issn>1651-1999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1r3DAUxEVpabZpz70VQaE3J0-W_KHekiVpAoGE0l56MbL03FWQpa0kE_a_r81uE1LI4fEO85thGEI-Mjhh0MLpfLyBCkCItpb1K7JidcUKJqV8TVaLWswyOyLvUroHYJwDvCVHjDHJGRcr8uvchWDoXcSUpoh0HXyOwVHr6UVK6LNVjl7tthgz-mSDp8obej1ulY3jLNMw0O_oZ-hy8jovwIPNG3r2G9-TN4NyCT8c_jH5eXnxY31V3Nx-u16f3RRasCYXCtuqR8G5Bs1K6Bk3ODQAXKKQA--NFqWRjapq0_RDqbhWxgDUIFrOq6rmx-TLPncbw58JU-5GmzQ6pzyGKXVNWUFbNgt4ugd1DClFHLpttKOKu45Bt8zZ_Tfn7Ph0iJ76Ec0Tf9hvBj4fAJW0ckNUXtv0yLVlLWCJ-bqnrB9CHNVDiM50We1ciP8s_OUO8pl5g8rljVYRu_swxXn69GL_v3DkoHg</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>MONDORF, ULRICH F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Blood Pressure Control in Essential Hypertension and Impairment of Renal Function with Age</title><author>MONDORF, ULRICH F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ae85be433c0c120b13def70039e49f3bdc42d97a56d7bf2a3cadd006048335563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Proteinuria - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONDORF, ULRICH F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood pressure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MONDORF, ULRICH F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Pressure Control in Essential Hypertension and Impairment of Renal Function with Age</atitle><jtitle>Blood pressure</jtitle><addtitle>Blood Press</addtitle><date>2000</date><risdate>2000</risdate><volume>9</volume><issue>5</issue><spage>293</spage><epage>297</epage><pages>293-297</pages><issn>0803-7051</issn><eissn>1651-1999</eissn><abstract>Hypertension has been recognized to be an important cause for the development of end-stage renal disease (ESRD). We assessed the quality of blood pressure control in 103 patients with essential hypertension and correlated renal function and age. Patients were stratified into three subgroups by their blood pressure level under current medication. Group 1 were hypertensive patients with normalized blood pressure (<140/90 mmHg, n = 25), group 2 patients with mild hypertension (140-159/90-99 mmHg, n = 43) and group 3 patients with moderate to severe hypertension (>160/100 mmHg, n = 35). A negative correlation between age and creatinine clearance (CCr) could be confirmed for patients of group 1 (correlation coefficient r1 = -0.56; p1 < 0.01) and group 2 (r2 = -0.55; p2 < 0.001). Furthermore the regression coefficient (m) of decline in CCr versus age was higher in group 2 patients (m2 = -1.83) than in group 1 (m1 = -1.30). In group 3 we found no correlation of renal function with age, indicating that age may not be the leading variable. Patients in group 1 were all within normal limits of age adjusted CCr, but 12% in group 2 and 23% in group 3 had impaired CCr. Furthermore proteinuria was found to be 20% (group 1), 26% (group 2) and 31% (group 3). This analysis provides further evidence of the importance of blood pressure control in essential hypertension to preserve renal function.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>11193134</pmid><doi>10.1080/080370500448696</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Physiological Adult Age Factors Aged Aged, 80 and over Aging - physiology Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Creatinine - blood Creatinine - urine Female Humans Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology Kidney - physiopathology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - prevention & control Male Medical sciences Middle Aged Proteinuria - etiology |
| title | Blood Pressure Control in Essential Hypertension and Impairment of Renal Function with Age |
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