Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus
This study was conducted in order to determine the chemical composition and the possible antinociceptive effects in mice of some species of Phyllanthus in vitro. The methanolic extracts obtained from callus cultures of P. fraternus, P. stipulatus and P. caroliniensis caused significant inhibition in...
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| Veröffentlicht in: | Pharmazie 2000-12, Vol.55 (12), p.945-946 |
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| creator | CATAPAN, E OTUKI, M. F VIANA, A. M YUNES, R. A BRESCIANI, L. F. V FERREIRA, J SANTOS, A. R. S CALIXTO, J. B CECHINEL-FILHO, V |
| description | This study was conducted in order to determine the chemical composition and the possible antinociceptive effects in mice of some species of Phyllanthus in vitro. The methanolic extracts obtained from callus cultures of P. fraternus, P. stipulatus and P. caroliniensis caused significant inhibition in to the late phase of the formalin test, whereas the extract from P. urinaria inhibited both neurogenic and inflammatory phases of the test. Conventional chromatographic methods (TLC, GC) permitted the detection of some steroids or triterpenes, including beta-sitosterol, glochidonol and glochidone, which seem be responsible for the antinociceptive effects of the callus extracts studied. |
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F ; VIANA, A. M ; YUNES, R. A ; BRESCIANI, L. F. V ; FERREIRA, J ; SANTOS, A. R. S ; CALIXTO, J. B ; CECHINEL-FILHO, V</creator><creatorcontrib>CATAPAN, E ; OTUKI, M. F ; VIANA, A. M ; YUNES, R. A ; BRESCIANI, L. F. V ; FERREIRA, J ; SANTOS, A. R. S ; CALIXTO, J. B ; CECHINEL-FILHO, V</creatorcontrib><description>This study was conducted in order to determine the chemical composition and the possible antinociceptive effects in mice of some species of Phyllanthus in vitro. The methanolic extracts obtained from callus cultures of P. fraternus, P. stipulatus and P. caroliniensis caused significant inhibition in to the late phase of the formalin test, whereas the extract from P. urinaria inhibited both neurogenic and inflammatory phases of the test. Conventional chromatographic methods (TLC, GC) permitted the detection of some steroids or triterpenes, including beta-sitosterol, glochidonol and glochidone, which seem be responsible for the antinociceptive effects of the callus extracts studied.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 11189874</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Acetaminophen - pharmacology ; Analgesics - chemistry ; Analgesics - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Aspirin - pharmacology ; Biological and medical sciences ; Brazil ; Culture Techniques ; Formaldehyde ; General pharmacology ; Male ; Medical sciences ; Mice ; Pain - chemically induced ; Pain - prevention & control ; Pain Measurement ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Conventional chromatographic methods (TLC, GC) permitted the detection of some steroids or triterpenes, including beta-sitosterol, glochidonol and glochidone, which seem be responsible for the antinociceptive effects of the callus extracts studied.</description><subject>Acetaminophen - pharmacology</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Aspirin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Culture Techniques</subject><subject>Formaldehyde</subject><subject>General pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pain - chemically induced</subject><subject>Pain - prevention & control</subject><subject>Pain Measurement</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Sterols - chemistry</subject><subject>Sterols - isolation & purification</subject><subject>Sterols - pharmacology</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLxDAYRbNQnHH0L0jAdSGvSdOlDL5gwFnoeviah42kTU1Scf69VUdXFy7nXLgnaEkIp1VNhVig85zfCGGSSXWGFpRS1ahaLNH7roPUg44hvnoNAYMu_sOXA4bBYN3Z_qfVsR9j9sXHAUeH5ypMGesplClZbD9Lmr2MXYo9zjZYXazBebTa2_wt7LpDCDCUbsoX6NRByPbymCv0cnf7vHmotk_3j5ubbTUyvi6VoFK5hoB1LTfMScnAtEy0VCmjNJdkzSyjLa150zjjqGiJ4mCJVkKCWEu-Qle_u-PU9tbsx-R7SIf93_cZuD4CkOdDLsGgff7nlKgJl_wLpyZjzQ</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>CATAPAN, E</creator><creator>OTUKI, M. 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Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Sterols - chemistry</topic><topic>Sterols - isolation & purification</topic><topic>Sterols - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CATAPAN, E</creatorcontrib><creatorcontrib>OTUKI, M. F</creatorcontrib><creatorcontrib>VIANA, A. M</creatorcontrib><creatorcontrib>YUNES, R. A</creatorcontrib><creatorcontrib>BRESCIANI, L. F. V</creatorcontrib><creatorcontrib>FERREIRA, J</creatorcontrib><creatorcontrib>SANTOS, A. R. S</creatorcontrib><creatorcontrib>CALIXTO, J. B</creatorcontrib><creatorcontrib>CECHINEL-FILHO, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CATAPAN, E</au><au>OTUKI, M. F</au><au>VIANA, A. M</au><au>YUNES, R. A</au><au>BRESCIANI, L. F. V</au><au>FERREIRA, J</au><au>SANTOS, A. R. S</au><au>CALIXTO, J. B</au><au>CECHINEL-FILHO, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>55</volume><issue>12</issue><spage>945</spage><epage>946</epage><pages>945-946</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>This study was conducted in order to determine the chemical composition and the possible antinociceptive effects in mice of some species of Phyllanthus in vitro. The methanolic extracts obtained from callus cultures of P. fraternus, P. stipulatus and P. caroliniensis caused significant inhibition in to the late phase of the formalin test, whereas the extract from P. urinaria inhibited both neurogenic and inflammatory phases of the test. Conventional chromatographic methods (TLC, GC) permitted the detection of some steroids or triterpenes, including beta-sitosterol, glochidonol and glochidone, which seem be responsible for the antinociceptive effects of the callus extracts studied.</abstract><cop>Eschborn</cop><pub>Govi</pub><pmid>11189874</pmid><tpages>2</tpages></addata></record> |
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| subjects | Acetaminophen - pharmacology Analgesics - chemistry Analgesics - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - pharmacology Biological and medical sciences Brazil Culture Techniques Formaldehyde General pharmacology Male Medical sciences Mice Pain - chemically induced Pain - prevention & control Pain Measurement Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Sterols - chemistry Sterols - isolation & purification Sterols - pharmacology |
| title | Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus |
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