Role of leukocytes in uterine hypoperfusion and fetal growth retardation induced by ischemia-reperfusion

1 Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582; and 2 Department of Clinical Research, National Ohkura Hospital, Tokyo 157-0063, Japan We investigated leukocyte involvement in uterine hypoperfusion and intrauterine fetal growth retardation (IUGR) indu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-03, Vol.280 (3), p.H1215-H1221
Hauptverfasser:	Miyakoshi, Kei, Ishimoto, Hitoshi, Nishimura, Osamu, Tanigaki, Shinji, Tanaka, Mamoru, Miyazaki, Toyohiko, Natori, Michiya, Yoshimura, Yasunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology CD18 Antigens - immunology Female Fetal Growth Retardation - immunology Fetal Growth Retardation - pathology Fetal Growth Retardation - physiopathology Fetal Weight Leukocytes - physiology Lymphocyte Function-Associated Antigen-1 - immunology Organ Size Placenta - blood supply Placenta - immunology Placenta - pathology Pregnancy Rats Reperfusion Injury - immunology Reperfusion Injury - pathology Reperfusion Injury - physiopathology Uterus - blood supply Uterus - immunology Uterus - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1 Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582; and 2 Department of Clinical Research, National Ohkura Hospital, Tokyo 157-0063, Japan We investigated leukocyte involvement in uterine hypoperfusion and intrauterine fetal growth retardation (IUGR) induced by ischemia-reperfusion (I/R) in Sprague-Dawley rats. On day 17 of gestation, leukocyte accumulation in the uterus and placenta subjected to 30 min of ischemia, followed by reperfusion, was assessed by measuring myeloperoxidase (MPO) activity. Uterine MPO activity was significantly higher after 1 h of reperfusion than it was before ischemia ( P
ISSN:	0363-6135 1522-1539
DOI:	10.1152/ajpheart.2001.280.3.h1215