Absence of Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis in an Italian Population
Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been r...
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| Veröffentlicht in: | Human heredity 2001-01, Vol.51 (3), p.177-179 |
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| container_title | Human heredity |
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| creator | Pascale, E. Tarani, L. Meglio, P. Businco, L. Battiloro, E. Cimino-Reale, G. Verna, R. D’Ambrosio, E. |
| description | Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an Italian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXI MCC polymorphism may not be involved in AD. |
| doi_str_mv | 10.1159/000053339 |
| format | Article |
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IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an Italian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXI MCC polymorphism may not be involved in AD.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000053339</identifier><identifier>PMID: 11173969</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Chymases ; Dermatitis, Atopic - enzymology ; Dermatitis, Atopic - genetics ; Female ; Genetic Variation ; Humans ; Infant ; Italy ; Male ; Mast Cells - enzymology ; Middle Aged ; Nucleic Acid Hybridization ; Original Paper ; Serine Endopeptidases - genetics</subject><ispartof>Human heredity, 2001-01, Vol.51 (3), p.177-179</ispartof><rights>2001 S. Karger AG</rights><rights>2001 S. Karger AG, Basel</rights><rights>Copyright 2001 S. Karger AG, Basel.</rights><rights>Copyright (c) 2001 S. 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IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an Italian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXI MCC polymorphism may not be involved in AD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chymases</subject><subject>Dermatitis, Atopic - enzymology</subject><subject>Dermatitis, Atopic - genetics</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Infant</subject><subject>Italy</subject><subject>Male</subject><subject>Mast Cells - enzymology</subject><subject>Middle Aged</subject><subject>Nucleic Acid Hybridization</subject><subject>Original Paper</subject><subject>Serine Endopeptidases - genetics</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAQQC0EokvLgTMCWRwqcUjx-CNxjquldCsVtQfgGtnJhGZJ4tR2hPrv8Xa3XQkhMQdb43l649EQ8gbYGYAqP7EUSghRPiMLkFxkjOX8OVmkZ8hUrvgReRXCJqWaFeIlOQKAQpR5uSDz0gYca6SupcsQXN2Z2LmRWoy_EUdq6A_jOzPGLRBvkX41IdIV9j1d3d4PJiC9wBGpGRu6jG7qavoZ_ZAksQu0S4KRXkbTJwW9cdPcP-hPyIvW9AFf7-9j8v3L-bfVOru6vrhcLa-yWhYyZkooCZBbJoSuW9nwdHBpLceC6VKUjS6YNVraNNm2pHQrQOVgoQAlAMUxOd15J-_uZgyxGrpQp8-bEd0cqoLlTBZc_xfkrATgkCfww1_gxs1-TENUPEXJWMkS9HEH1d6F4LGtJt8Nxt9XwKrtxqqnjSX2_V442wGbA7lf0aHjL-N_on8C1uvzB0M1NW2C3v4TeuzxblfdhOgORakVywVo8Qc8pqum</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Pascale, E.</creator><creator>Tarani, L.</creator><creator>Meglio, P.</creator><creator>Businco, L.</creator><creator>Battiloro, E.</creator><creator>Cimino-Reale, G.</creator><creator>Verna, R.</creator><creator>D’Ambrosio, E.</creator><general>S. 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Academic</collection><jtitle>Human heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascale, E.</au><au>Tarani, L.</au><au>Meglio, P.</au><au>Businco, L.</au><au>Battiloro, E.</au><au>Cimino-Reale, G.</au><au>Verna, R.</au><au>D’Ambrosio, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis in an Italian Population</atitle><jtitle>Human heredity</jtitle><addtitle>Hum Hered</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>51</volume><issue>3</issue><spage>177</spage><epage>179</epage><pages>177-179</pages><issn>0001-5652</issn><eissn>1423-0062</eissn><abstract>Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. IgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an Italian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXI MCC polymorphism may not be involved in AD.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>11173969</pmid><doi>10.1159/000053339</doi><tpages>3</tpages></addata></record> |
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| ispartof | Human heredity, 2001-01, Vol.51 (3), p.177-179 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Karger Journals |
| subjects | Adolescent Adult Aged Child Child, Preschool Chymases Dermatitis, Atopic - enzymology Dermatitis, Atopic - genetics Female Genetic Variation Humans Infant Italy Male Mast Cells - enzymology Middle Aged Nucleic Acid Hybridization Original Paper Serine Endopeptidases - genetics |
| title | Absence of Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis in an Italian Population |
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