Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin

BCG, the attenuated strain of Mycobacterium bovis, has been widely used as a vaccine against tuberculosis and is thus an important candidate as a live carrier for multiple antigens. With the aim of developing a recombinant BCG (rBCG) vaccine against diphtheria, pertussis, and tetanus (DPT), we analy...

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Veröffentlicht in:	Infection and immunity 2001-02, Vol.69 (2), p.869
Hauptverfasser:	Miyaji, E N, Mazzantini, R P, Dias, W O, Nascimento, A L, Marcovistz, R, Matos, D S, Raw, I, Winter, N, Gicquel, B, Rappuoli, R, Leite, L C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - biosynthesis Bacterial Proteins - immunology BCG Vaccine - immunology Diphtheria Toxin - immunology Immunization Male Mice Mice, Inbred BALB C Vaccines, Synthetic - immunology
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