Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi

Hematopoietic stem cells (HSCs) are characterized by their dual abilities to undergo differentiation into multiple hematopoietic cell lineages or to undergo self-renewal. The molecular basis of these properties remains poorly understood. Recently the piwi gene was found in the embryonic germline ste...

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Veröffentlicht in:	Blood 2001-01, Vol.97 (2), p.426-434
Hauptverfasser:	SHARMA, Arun K, NELSON, Mary C, BRANDT, John E, WESSMAN, Maija, MAHMUD, Nadim, WELLER, Kevin P, HOFFMAN, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 Apoptosis - drug effects Argonaute Proteins Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cell Culture Techniques Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Division - drug effects Cell physiology Chromosome Mapping Chromosomes, Human, Pair 12 - genetics Cloning, Molecular DNA, Complementary Drosophila - chemistry Drosophila Proteins Formazans Fundamental and applied biological sciences. Psychology Humans Insect Proteins - chemistry Molecular and cellular biology Molecular Sequence Data Proteins - genetics Proteins - metabolism Proteins - pharmacology RNA-Induced Silencing Complex Sequence Alignment Sequence Homology, Amino Acid Stem Cells - cytology Stem Cells - immunology Stem Cells - metabolism Tetrazolium Salts Transfection Tumor Cells, Cultured
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