A Genome Survey Indicates a Possible Susceptibility Locus for Bipolar Disorder on Chromosome 22
Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and e...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (2), p.585-590 |
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| creator | Kelsoe, John R. Spence, M. Anne Loetscher, Erika Foguet, Montserrat Sadovnick, A. Dessa Remick, Ronald A. Flodman, Pamela Khristich, Jason Mroczkowski-Parker, Zofi Brown, John L. Masser, Diane Ungerleider, Sharon Rapaport, Mark H. Wishart, William L. Luebbert, Hermann |
| description | Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders. |
| doi_str_mv | 10.1073/pnas.98.2.585 |
| format | Article |
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Anne ; Loetscher, Erika ; Foguet, Montserrat ; Sadovnick, A. Dessa ; Remick, Ronald A. ; Flodman, Pamela ; Khristich, Jason ; Mroczkowski-Parker, Zofi ; Brown, John L. ; Masser, Diane ; Ungerleider, Sharon ; Rapaport, Mark H. ; Wishart, William L. ; Luebbert, Hermann</creator><creatorcontrib>Kelsoe, John R. ; Spence, M. Anne ; Loetscher, Erika ; Foguet, Montserrat ; Sadovnick, A. Dessa ; Remick, Ronald A. ; Flodman, Pamela ; Khristich, Jason ; Mroczkowski-Parker, Zofi ; Brown, John L. ; Masser, Diane ; Ungerleider, Sharon ; Rapaport, Mark H. ; Wishart, William L. ; Luebbert, Hermann</creatorcontrib><description>Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.98.2.585</identifier><identifier>PMID: 11149935</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Biological Sciences ; Bipolar disorder ; Bipolar Disorder - classification ; Bipolar Disorder - epidemiology ; Bipolar Disorder - genetics ; British Columbia - epidemiology ; California - epidemiology ; chromosome 10 ; chromosome 13 ; chromosome 21 ; chromosome 22 ; chromosome 3 ; chromosome 5 ; Chromosome Mapping ; Chromosomes ; Chromosomes, Human, Pair 10 - genetics ; Chromosomes, Human, Pair 13 - genetics ; Chromosomes, Human, Pair 21 - genetics ; Chromosomes, Human, Pair 22 - genetics ; Chromosomes, Human, Pair 3 - genetics ; Chromosomes, Human, Pair 5 - genetics ; Disease models ; Disorders ; Female ; Genetic loci ; Genetic Predisposition to Disease ; Genome, Human ; Genomes ; Genomics ; Genotype ; Humans ; Lod Score ; Male ; Manic depression ; Medical genetics ; Microsatellite Repeats ; Polymerase Chain Reaction ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - genetics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (2), p.585-590</ispartof><rights>Copyright 1993-2001 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Jan 16, 2001</rights><rights>Copyright © 2001, The National Academy of Sciences 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4265-ce791c09c6036dd89ce1e5066d879d5ba8523a2c626e7366a910b0c7d8740f363</citedby><cites>FETCH-LOGICAL-c4265-ce791c09c6036dd89ce1e5066d879d5ba8523a2c626e7366a910b0c7d8740f363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/98/2.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3054727$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3054727$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11149935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelsoe, John R.</creatorcontrib><creatorcontrib>Spence, M. Anne</creatorcontrib><creatorcontrib>Loetscher, Erika</creatorcontrib><creatorcontrib>Foguet, Montserrat</creatorcontrib><creatorcontrib>Sadovnick, A. Dessa</creatorcontrib><creatorcontrib>Remick, Ronald A.</creatorcontrib><creatorcontrib>Flodman, Pamela</creatorcontrib><creatorcontrib>Khristich, Jason</creatorcontrib><creatorcontrib>Mroczkowski-Parker, Zofi</creatorcontrib><creatorcontrib>Brown, John L.</creatorcontrib><creatorcontrib>Masser, Diane</creatorcontrib><creatorcontrib>Ungerleider, Sharon</creatorcontrib><creatorcontrib>Rapaport, Mark H.</creatorcontrib><creatorcontrib>Wishart, William L.</creatorcontrib><creatorcontrib>Luebbert, Hermann</creatorcontrib><title>A Genome Survey Indicates a Possible Susceptibility Locus for Bipolar Disorder on Chromosome 22</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.</description><subject>Biological Sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - classification</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - genetics</subject><subject>British Columbia - epidemiology</subject><subject>California - epidemiology</subject><subject>chromosome 10</subject><subject>chromosome 13</subject><subject>chromosome 21</subject><subject>chromosome 22</subject><subject>chromosome 3</subject><subject>chromosome 5</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 10 - genetics</subject><subject>Chromosomes, Human, Pair 13 - genetics</subject><subject>Chromosomes, Human, Pair 21 - genetics</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>Chromosomes, Human, Pair 5 - genetics</subject><subject>Disease models</subject><subject>Disorders</subject><subject>Female</subject><subject>Genetic loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Male</subject><subject>Manic depression</subject><subject>Medical genetics</subject><subject>Microsatellite Repeats</subject><subject>Polymerase Chain Reaction</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EotvCkRtCFlK5ZRl_xxKXskCptBJIwNlyHId6lcSpnVTsf09Cl7ZwgJMP7_eeZ-Yh9IzAmoBir4fe5rUu13QtSvEArQhoUkiu4SFaAVBVlJzyI3Sc8w4AtCjhMToihHCtmVghc4bPfR87j79M6drv8UVfB2dHn7HFn2POoWoXLTs_jKEKbRj3eBvdlHETE34bhtjahN-FHFPtE4493lym2MW8ZFL6BD1qbJv908N7gr59eP9187HYfjq_2JxtC8epFIXzShMH2klgsq5L7TzxAqSsS6VrUdlSUGapk1R6xaS0mkAFTs0yh4ZJdoLe3OQOU9X52vl-TLY1QwqdTXsTbTB_Kn24NN_jtSFcMjLbXx3sKV5NPo-mC_PKbWt7H6dslNRSScH-CxKluFJiGejlX-AuTqmfb2AoEE44__VtcQO5NJ86-eZ2YAJmqdcs9RpdGmrmemf-xf0t7-hDnzPw_AAsvt_yPf_pP2TTTG07-h_jXcwujzHdggwEV1Sxn1SjwSo</recordid><startdate>20010116</startdate><enddate>20010116</enddate><creator>Kelsoe, John R.</creator><creator>Spence, M. Anne</creator><creator>Loetscher, Erika</creator><creator>Foguet, Montserrat</creator><creator>Sadovnick, A. Dessa</creator><creator>Remick, Ronald A.</creator><creator>Flodman, Pamela</creator><creator>Khristich, Jason</creator><creator>Mroczkowski-Parker, Zofi</creator><creator>Brown, John L.</creator><creator>Masser, Diane</creator><creator>Ungerleider, Sharon</creator><creator>Rapaport, Mark H.</creator><creator>Wishart, William L.</creator><creator>Luebbert, Hermann</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010116</creationdate><title>A Genome Survey Indicates a Possible Susceptibility Locus for Bipolar Disorder on Chromosome 22</title><author>Kelsoe, John R. ; Spence, M. Anne ; Loetscher, Erika ; Foguet, Montserrat ; Sadovnick, A. Dessa ; Remick, Ronald A. ; Flodman, Pamela ; Khristich, Jason ; Mroczkowski-Parker, Zofi ; Brown, John L. ; Masser, Diane ; Ungerleider, Sharon ; Rapaport, Mark H. ; Wishart, William L. ; Luebbert, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4265-ce791c09c6036dd89ce1e5066d879d5ba8523a2c626e7366a910b0c7d8740f363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological Sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - classification</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - genetics</topic><topic>British Columbia - epidemiology</topic><topic>California - epidemiology</topic><topic>chromosome 10</topic><topic>chromosome 13</topic><topic>chromosome 21</topic><topic>chromosome 22</topic><topic>chromosome 3</topic><topic>chromosome 5</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 10 - genetics</topic><topic>Chromosomes, Human, Pair 13 - genetics</topic><topic>Chromosomes, Human, Pair 21 - genetics</topic><topic>Chromosomes, Human, Pair 22 - genetics</topic><topic>Chromosomes, Human, Pair 3 - genetics</topic><topic>Chromosomes, Human, Pair 5 - genetics</topic><topic>Disease models</topic><topic>Disorders</topic><topic>Female</topic><topic>Genetic loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Male</topic><topic>Manic depression</topic><topic>Medical genetics</topic><topic>Microsatellite Repeats</topic><topic>Polymerase Chain Reaction</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelsoe, John R.</creatorcontrib><creatorcontrib>Spence, M. 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Anne</au><au>Loetscher, Erika</au><au>Foguet, Montserrat</au><au>Sadovnick, A. Dessa</au><au>Remick, Ronald A.</au><au>Flodman, Pamela</au><au>Khristich, Jason</au><au>Mroczkowski-Parker, Zofi</au><au>Brown, John L.</au><au>Masser, Diane</au><au>Ungerleider, Sharon</au><au>Rapaport, Mark H.</au><au>Wishart, William L.</au><au>Luebbert, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Genome Survey Indicates a Possible Susceptibility Locus for Bipolar Disorder on Chromosome 22</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2001-01-16</date><risdate>2001</risdate><volume>98</volume><issue>2</issue><spage>585</spage><epage>590</epage><pages>585-590</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>11149935</pmid><doi>10.1073/pnas.98.2.585</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological Sciences Bipolar disorder Bipolar Disorder - classification Bipolar Disorder - epidemiology Bipolar Disorder - genetics British Columbia - epidemiology California - epidemiology chromosome 10 chromosome 13 chromosome 21 chromosome 22 chromosome 3 chromosome 5 Chromosome Mapping Chromosomes Chromosomes, Human, Pair 10 - genetics Chromosomes, Human, Pair 13 - genetics Chromosomes, Human, Pair 21 - genetics Chromosomes, Human, Pair 22 - genetics Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 5 - genetics Disease models Disorders Female Genetic loci Genetic Predisposition to Disease Genome, Human Genomes Genomics Genotype Humans Lod Score Male Manic depression Medical genetics Microsatellite Repeats Polymerase Chain Reaction Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics |
| title | A Genome Survey Indicates a Possible Susceptibility Locus for Bipolar Disorder on Chromosome 22 |
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