Neurotensin Modulates the Electrical Activity of Frog Pituitary Melanotropes via Activation of a G-Protein-Coupled Receptor Pharmacologically Related to Both the NTS1 and nts2 Receptors of Mammals

The primary structure of frog neurotensin (fNT) has recently been determined and it has been shown that fNT is a potent stimulator of α-MSH secretion by frog pituitary melanotropes. In the present study, we have investigated the effects of fNT on the electrical activity of cultured frog melanotropes...

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Veröffentlicht in:	Neuroendocrinology 2000-12, Vol.72 (6), p.379-391
Hauptverfasser:	Belmeguenai, Amor, Vaudry, Hubert, Leprince, Jérôme, Vivet, Bertrand, Cavelier, Florine, Martinez, Jean, Louiset, Estelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane Adamantane - analogs & derivatives Adamantane - pharmacology Animals Anura Cell Behavior Cells, Cultured Cellular Biology Chemical Sciences GTP-Binding Protein alpha Subunits, Gq-G11 Guanosine 5'-O-(3-Thiotriphosphate) Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Diphosphate Guanosine Diphosphate - analogs & derivatives Guanosine Diphosphate - pharmacology Heterotrimeric GTP-Binding Proteins Heterotrimeric GTP-Binding Proteins - metabolism Imidazoles Imidazoles - pharmacology Life Sciences Ligands Male Mammals Medicinal Chemistry Melanocytes Melanocytes - drug effects Melanocytes - metabolism melanotropes Membrane Potentials Membrane Potentials - drug effects Membrane Potentials - physiology Neurobiology Neurons and Cognition Neurotensin Neurotensin - metabolism Neurotensin - pharmacology neurotensin receptors Patch-Clamp Techniques Peptide Fragments Peptide Fragments - metabolism Peptide Fragments - pharmacology Pharmaceutical sciences Pharmacology Pituitary Cell Biology Pituitary Gland Pituitary Gland - cytology Pyrazoles Pyrazoles - pharmacology Quinolines Quinolines - pharmacology Rana Rana ridibunda Receptors, Neurotensin Receptors, Neurotensin - metabolism Signal Transduction Signal Transduction - drug effects Signal Transduction - physiology Thionucleotides Thionucleotides - pharmacology
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