Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress
Background: Bowel washout solutions may damage colonic mucosa and cause shallow ulceration, which may result in diagnostic errors and complications. The effects of polyethylene glycol (PEG) and sodium phosphate on rat colon were investigated histologically and by measurement of indicators of oxidati...
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| Veröffentlicht in: | British journal of surgery 2001-01, Vol.88 (1), p.85-89 |
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| container_title | British journal of surgery |
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| creator | Coskun, A. Uzunkoy, A. Duzgun, S. A. Bozer, M. Ozardali, I. Vural, H. |
| description | Background:
Bowel washout solutions may damage colonic mucosa and cause shallow ulceration, which may result in diagnostic errors and complications. The effects of polyethylene glycol (PEG) and sodium phosphate on rat colon were investigated histologically and by measurement of indicators of oxidative stress.
Methods:
Thirty Wistar albino rats were divided into three groups and received PEG, sodium phosphate or tap water alone (control). After 8 h, histological changes in colonic mucosa were evaluated. The tissue concentration of malonyldialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) in colon homogenates was also measured.
Results:
Animals in the sodium phosphate and PEG groups had significantly more colonic mucosal damage than controls, the damage induced by sodium phosphate being worse than that caused by PEG. MDA levels were significantly higher in the sodium phosphate and PEG groups than in controls and were higher in the sodium phosphate group than in the PEG group, whereas differences in SOD and GSH‐Px activities were significant only between control and both sodium phosphate and PEG groups.
Conclusion:
Sodium phosphate and PEG cause histological damage and trigger oxidative stress on colonic mucosa. The tissue damage and oxidative stress induced by sodium phosphate is more profound than that produced by PEG. © 2001 British Journal of Surgery Society Ltd |
| doi_str_mv | 10.1046/j.1365-2168.2001.01608.x |
| format | Article |
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Bowel washout solutions may damage colonic mucosa and cause shallow ulceration, which may result in diagnostic errors and complications. The effects of polyethylene glycol (PEG) and sodium phosphate on rat colon were investigated histologically and by measurement of indicators of oxidative stress.
Methods:
Thirty Wistar albino rats were divided into three groups and received PEG, sodium phosphate or tap water alone (control). After 8 h, histological changes in colonic mucosa were evaluated. The tissue concentration of malonyldialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) in colon homogenates was also measured.
Results:
Animals in the sodium phosphate and PEG groups had significantly more colonic mucosal damage than controls, the damage induced by sodium phosphate being worse than that caused by PEG. MDA levels were significantly higher in the sodium phosphate and PEG groups than in controls and were higher in the sodium phosphate group than in the PEG group, whereas differences in SOD and GSH‐Px activities were significant only between control and both sodium phosphate and PEG groups.
Conclusion:
Sodium phosphate and PEG cause histological damage and trigger oxidative stress on colonic mucosa. The tissue damage and oxidative stress induced by sodium phosphate is more profound than that produced by PEG. © 2001 British Journal of Surgery Society Ltd</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1046/j.1365-2168.2001.01608.x</identifier><identifier>PMID: 11136317</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cathartics - adverse effects ; Colonic Diseases - chemically induced ; Colonic Diseases - pathology ; Drug toxicity and drugs side effects treatment ; Glutathione Peroxidase - analysis ; Male ; Malondialdehyde - analysis ; Medical sciences ; Oxidative Stress - drug effects ; Pharmacology. Drug treatments ; Phosphates - adverse effects ; Polyethylene Glycols - adverse effects ; Rats ; Rats, Wistar ; Superoxide Dismutase - analysis ; Surface-Active Agents - adverse effects ; Toxicity: digestive system</subject><ispartof>British journal of surgery, 2001-01, Vol.88 (1), p.85-89</ispartof><rights>2001 British Journal of Surgery Society Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4971-a2cec738898b2a418326bf447299ca4f1cdc6f9d234f36ef6e5bb78e4a7e931c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2168.2001.01608.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2168.2001.01608.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=882511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11136317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coskun, A.</creatorcontrib><creatorcontrib>Uzunkoy, A.</creatorcontrib><creatorcontrib>Duzgun, S. A.</creatorcontrib><creatorcontrib>Bozer, M.</creatorcontrib><creatorcontrib>Ozardali, I.</creatorcontrib><creatorcontrib>Vural, H.</creatorcontrib><title>Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
Bowel washout solutions may damage colonic mucosa and cause shallow ulceration, which may result in diagnostic errors and complications. The effects of polyethylene glycol (PEG) and sodium phosphate on rat colon were investigated histologically and by measurement of indicators of oxidative stress.
Methods:
Thirty Wistar albino rats were divided into three groups and received PEG, sodium phosphate or tap water alone (control). After 8 h, histological changes in colonic mucosa were evaluated. The tissue concentration of malonyldialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) in colon homogenates was also measured.
Results:
Animals in the sodium phosphate and PEG groups had significantly more colonic mucosal damage than controls, the damage induced by sodium phosphate being worse than that caused by PEG. MDA levels were significantly higher in the sodium phosphate and PEG groups than in controls and were higher in the sodium phosphate group than in the PEG group, whereas differences in SOD and GSH‐Px activities were significant only between control and both sodium phosphate and PEG groups.
Conclusion:
Sodium phosphate and PEG cause histological damage and trigger oxidative stress on colonic mucosa. The tissue damage and oxidative stress induced by sodium phosphate is more profound than that produced by PEG. © 2001 British Journal of Surgery Society Ltd</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cathartics - adverse effects</subject><subject>Colonic Diseases - chemically induced</subject><subject>Colonic Diseases - pathology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Glutathione Peroxidase - analysis</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphates - adverse effects</subject><subject>Polyethylene Glycols - adverse effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - analysis</subject><subject>Surface-Active Agents - adverse effects</subject><subject>Toxicity: digestive system</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1r2zAUhsVYWdNsf2EIdm1XX5Zk2M1WsrSlpBftGOxGyPJxosyxjWWv9r-v3bTp1TlwnveF8yCEKYkpEfJyH1Muk4hRqWNGCI0JlUTHwwe0OB0-ogUhREWUM36OLkLYTyAnCfuEzimdME7VAm1XQwOtP0DV2RKHOvf9ATe7OjQ72wG2VY6buhyh240lVIC35ejqEvsq7x3gaa0r73DnQ-gB5_Zgt8dQPfjcdv4_4NC1EMJndFbYMsCX17lEv3-tHq-uo7v79c3Vj7vIiVTRyDIHTnGtU50xK6jmTGaFEIqlqbOioC53skhzxkXBJRQSkixTGoRVkHLq-BJ9PfY2fXaA3DTTb7YdzdvHE_DtFbDB2bJobeV8OHFas2RCl-j7kXryJYzvLcTM_s3ezJrNrNnM_s2LfzOYn7cPgs_x6Bj3oYPhFLftPyMVV4n5s1kbrshmk0hp_vJnWX-Jpg</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Coskun, A.</creator><creator>Uzunkoy, A.</creator><creator>Duzgun, S. A.</creator><creator>Bozer, M.</creator><creator>Ozardali, I.</creator><creator>Vural, H.</creator><general>Blackwell Science Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200101</creationdate><title>Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress</title><author>Coskun, A. ; Uzunkoy, A. ; Duzgun, S. A. ; Bozer, M. ; Ozardali, I. ; Vural, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4971-a2cec738898b2a418326bf447299ca4f1cdc6f9d234f36ef6e5bb78e4a7e931c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cathartics - adverse effects</topic><topic>Colonic Diseases - chemically induced</topic><topic>Colonic Diseases - pathology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Glutathione Peroxidase - analysis</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphates - adverse effects</topic><topic>Polyethylene Glycols - adverse effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - analysis</topic><topic>Surface-Active Agents - adverse effects</topic><topic>Toxicity: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coskun, A.</creatorcontrib><creatorcontrib>Uzunkoy, A.</creatorcontrib><creatorcontrib>Duzgun, S. A.</creatorcontrib><creatorcontrib>Bozer, M.</creatorcontrib><creatorcontrib>Ozardali, I.</creatorcontrib><creatorcontrib>Vural, H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coskun, A.</au><au>Uzunkoy, A.</au><au>Duzgun, S. A.</au><au>Bozer, M.</au><au>Ozardali, I.</au><au>Vural, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2001-01</date><risdate>2001</risdate><volume>88</volume><issue>1</issue><spage>85</spage><epage>89</epage><pages>85-89</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
Bowel washout solutions may damage colonic mucosa and cause shallow ulceration, which may result in diagnostic errors and complications. The effects of polyethylene glycol (PEG) and sodium phosphate on rat colon were investigated histologically and by measurement of indicators of oxidative stress.
Methods:
Thirty Wistar albino rats were divided into three groups and received PEG, sodium phosphate or tap water alone (control). After 8 h, histological changes in colonic mucosa were evaluated. The tissue concentration of malonyldialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) in colon homogenates was also measured.
Results:
Animals in the sodium phosphate and PEG groups had significantly more colonic mucosal damage than controls, the damage induced by sodium phosphate being worse than that caused by PEG. MDA levels were significantly higher in the sodium phosphate and PEG groups than in controls and were higher in the sodium phosphate group than in the PEG group, whereas differences in SOD and GSH‐Px activities were significant only between control and both sodium phosphate and PEG groups.
Conclusion:
Sodium phosphate and PEG cause histological damage and trigger oxidative stress on colonic mucosa. The tissue damage and oxidative stress induced by sodium phosphate is more profound than that produced by PEG. © 2001 British Journal of Surgery Society Ltd</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11136317</pmid><doi>10.1046/j.1365-2168.2001.01608.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 2001-01, Vol.88 (1), p.85-89 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals |
| subjects | Animals Biological and medical sciences Cathartics - adverse effects Colonic Diseases - chemically induced Colonic Diseases - pathology Drug toxicity and drugs side effects treatment Glutathione Peroxidase - analysis Male Malondialdehyde - analysis Medical sciences Oxidative Stress - drug effects Pharmacology. Drug treatments Phosphates - adverse effects Polyethylene Glycols - adverse effects Rats Rats, Wistar Superoxide Dismutase - analysis Surface-Active Agents - adverse effects Toxicity: digestive system |
| title | Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress |
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