Myoglobin: A Scavenger of Bioactive NO

The present study explored the role of myoglobin (Mb) in cardiac NO homeostasis and its functional relevance by employing isolated hearts of wild-type (WT) and myoglobin knockout mice.1H NMR spectroscopy was used to measure directly the conversion of oxygenated Mb (MbO2) to metmyoglobin (metMb) by r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (2), p.735-740
Hauptverfasser:	Flögel, Ulrich, Merx, Marc W., Gödecke, Axel, Ulrich K. M. Decking, Schrader, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Bradykinin - pharmacology Cardiac output Coronary Circulation - drug effects Cytosol - metabolism Dose response relationship Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Heart Heart - drug effects Homeostasis Isothiuronium - analogs & derivatives Isothiuronium - pharmacology Magnetic Resonance Spectroscopy Mammals Metmyoglobin - biosynthesis Mice Mice, Knockout Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Models, Biological Myocardial Contraction - drug effects Myocardium Myocardium - metabolism Myoglobin - genetics Myoglobin - metabolism Nitrates Nitrates - metabolism Nitric Oxide - metabolism Nitric Oxide - pharmacology Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - pharmacology Oxidation-Reduction Oxygen Perfusion Rodents Spectroscopy Vasodilation Vasodilation - drug effects Vasodilator Agents - pharmacology
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