Biliary obstruction exacerbates the hepatic microvascular inflammatory response to endotoxin

Gram-negative sepsis is a serious complication for patients with obstructive jaundice. The present study was conducted to elucidate the response of hepatic microcirculation to endotoxin 2 weeks after bile duct ligation (BDL) or sham-operation in rats. Two hours after lipopolysaccharide (LPS) injecti...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2000-12, Vol.14 (6), p.599-604
Hauptverfasser:	ITO, Yoshiya, MACHEN, Nancy W, URBASCHEK, Renate, MCCUSKEY, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cholestasis - complications Emergency and intensive care: infection, septic shock Endothelium - drug effects Endothelium - pathology Endotoxins - toxicity Hepatitis - etiology Hepatitis - pathology Humans Intensive care medicine Leukocytes - drug effects Leukocytes - pathology Lipopolysaccharides - toxicity Liver Circulation - drug effects Male Medical sciences Microcirculation - drug effects Phagocytosis - drug effects Rats Rats, Sprague-Dawley Sepsis - etiology
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