Identification and characterization of Podophyllum emodi by API-LC/MS/MS
An API‐LC/MS/MS method was developed for the identification of the medicinal herb Podophyllum emodi based on the profile of its aryltetrahydronapthalene and related lignan marker compounds. This was done by matching the structural information from the tandem mass spectrometric data with those lignan...
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| Veröffentlicht in: | Journal of mass spectrometry. 2000-11, Vol.35 (11), p.1246-1251 |
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| container_issue | 11 |
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| container_title | Journal of mass spectrometry. |
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| creator | Wong, Siu-Kay Tsui, Shu-Ki Kwan, Sik-Yiu Su, Xiao-Li Lin, Rui-Chao |
| description | An API‐LC/MS/MS method was developed for the identification of the medicinal herb Podophyllum emodi based on the profile of its aryltetrahydronapthalene and related lignan marker compounds. This was done by matching the structural information from the tandem mass spectrometric data with those lignan marker compounds already reported for the herb. The method could be employed in the absence of reference standards for the markers and was particularly useful in view of the scarcity of supply of these chemical standards. It has been used successfully to differentiate Podophyllum emodi from two commonly used medicinal herbs of a different genus but having similar appearance, Radix clematidis and Radix gentiana, as well as a closely related herb, Podophyllum peltatum. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/1096-9888(200011)35:11<1246::AID-JMS55>3.0.CO;2-L |
| format | Article |
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This was done by matching the structural information from the tandem mass spectrometric data with those lignan marker compounds already reported for the herb. The method could be employed in the absence of reference standards for the markers and was particularly useful in view of the scarcity of supply of these chemical standards. It has been used successfully to differentiate Podophyllum emodi from two commonly used medicinal herbs of a different genus but having similar appearance, Radix clematidis and Radix gentiana, as well as a closely related herb, Podophyllum peltatum. Copyright © 2000 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1076-5174</identifier><identifier>EISSN: 1096-9888</identifier><identifier>DOI: 10.1002/1096-9888(200011)35:11<1246::AID-JMS55>3.0.CO;2-L</identifier><identifier>PMID: 11114081</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>API-LC/MS/MS ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers - chemistry ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal - analysis ; Drugs, Chinese Herbal - chemistry ; General pharmacology ; Lignans - analysis ; Lignans - chemistry ; marker compound profile ; Mass Spectrometry - methods ; Medical sciences ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; Plants, Toxic ; Podophyllotoxin - analogs & derivatives ; Podophyllotoxin - analysis ; Podophyllotoxin - chemistry ; Podophyllum - chemistry ; Podophyllum emodi ; Reference Standards ; Tetrahydronaphthalenes - analysis ; Tetrahydronaphthalenes - chemistry</subject><ispartof>Journal of mass spectrometry., 2000-11, Vol.35 (11), p.1246-1251</ispartof><rights>Copyright © 2000 John Wiley & Sons, Ltd.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1096-9888%28200011%2935%3A11%3C1246%3A%3AAID-JMS55%3E3.0.CO%3B2-L$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1096-9888%28200011%2935%3A11%3C1246%3A%3AAID-JMS55%3E3.0.CO%3B2-L$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=826480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11114081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Siu-Kay</creatorcontrib><creatorcontrib>Tsui, Shu-Ki</creatorcontrib><creatorcontrib>Kwan, Sik-Yiu</creatorcontrib><creatorcontrib>Su, Xiao-Li</creatorcontrib><creatorcontrib>Lin, Rui-Chao</creatorcontrib><title>Identification and characterization of Podophyllum emodi by API-LC/MS/MS</title><title>Journal of mass spectrometry.</title><addtitle>J. Mass Spectrom</addtitle><description>An API‐LC/MS/MS method was developed for the identification of the medicinal herb Podophyllum emodi based on the profile of its aryltetrahydronapthalene and related lignan marker compounds. This was done by matching the structural information from the tandem mass spectrometric data with those lignan marker compounds already reported for the herb. The method could be employed in the absence of reference standards for the markers and was particularly useful in view of the scarcity of supply of these chemical standards. It has been used successfully to differentiate Podophyllum emodi from two commonly used medicinal herbs of a different genus but having similar appearance, Radix clematidis and Radix gentiana, as well as a closely related herb, Podophyllum peltatum. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>API-LC/MS/MS</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drugs, Chinese Herbal - analysis</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>General pharmacology</subject><subject>Lignans - analysis</subject><subject>Lignans - chemistry</subject><subject>marker compound profile</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Plants, Toxic</subject><subject>Podophyllotoxin - analogs & derivatives</subject><subject>Podophyllotoxin - analysis</subject><subject>Podophyllotoxin - chemistry</subject><subject>Podophyllum - chemistry</subject><subject>Podophyllum emodi</subject><subject>Reference Standards</subject><subject>Tetrahydronaphthalenes - analysis</subject><subject>Tetrahydronaphthalenes - chemistry</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkGtr2zAUhsVYWa9_YRj6ZfugVHdL2RgE95biNmXZ2o8HWZKpNicOdkqb_vrac5eKAxKH9zwHPQgZSkaUEHZCiVHYaK2_MEIIpV-5HFP6nTKhxuPJ9BRfXc-l_MFHZJTNvjGcf0B725mP_TtVWNJU7KL9tv3TMYwR6hPapd0RRNM9dDn1YbmOZXR2HetlYpc-cQ-2sW4dmvgyNOsyua19vXrYVNXjIgmL2sek2CST2ynOs5PreVeHaKe0VRuO3u4D9Pv87Fd2ifPZxTSb5DhyYSSmzFBnpBUsKEZk0KwUhVOeFY5QkxbaKCnKVGluOLPWk7IUihU61T445hk_QJ8H7uqxWAQPqyYubLOB_1_qAsdvAds6W5WNXbrYbnOaKaFJl5oPqadYhc07hUBvHnqL0FuEwTxw2W2A3jx04uGfeOBAIJsBg3xodFQ8UGO7Ds9bqm3-gkp5KuH-5gJ-3pu7K2UYnPNXyTqHLg</recordid><startdate>200011</startdate><enddate>200011</enddate><creator>Wong, Siu-Kay</creator><creator>Tsui, Shu-Ki</creator><creator>Kwan, Sik-Yiu</creator><creator>Su, Xiao-Li</creator><creator>Lin, Rui-Chao</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200011</creationdate><title>Identification and characterization of Podophyllum emodi by API-LC/MS/MS</title><author>Wong, Siu-Kay ; Tsui, Shu-Ki ; Kwan, Sik-Yiu ; Su, Xiao-Li ; Lin, Rui-Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3495-1291c95a42e6205e82f4bc6d2bc0197b89654f7683932aad0ff462b878dec2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>API-LC/MS/MS</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drugs, Chinese Herbal - analysis</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>General pharmacology</topic><topic>Lignans - analysis</topic><topic>Lignans - chemistry</topic><topic>marker compound profile</topic><topic>Mass Spectrometry - methods</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Plants, Toxic</topic><topic>Podophyllotoxin - analogs & derivatives</topic><topic>Podophyllotoxin - analysis</topic><topic>Podophyllotoxin - chemistry</topic><topic>Podophyllum - chemistry</topic><topic>Podophyllum emodi</topic><topic>Reference Standards</topic><topic>Tetrahydronaphthalenes - analysis</topic><topic>Tetrahydronaphthalenes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Siu-Kay</creatorcontrib><creatorcontrib>Tsui, Shu-Ki</creatorcontrib><creatorcontrib>Kwan, Sik-Yiu</creatorcontrib><creatorcontrib>Su, Xiao-Li</creatorcontrib><creatorcontrib>Lin, Rui-Chao</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Siu-Kay</au><au>Tsui, Shu-Ki</au><au>Kwan, Sik-Yiu</au><au>Su, Xiao-Li</au><au>Lin, Rui-Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and characterization of Podophyllum emodi by API-LC/MS/MS</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2000-11</date><risdate>2000</risdate><volume>35</volume><issue>11</issue><spage>1246</spage><epage>1251</epage><pages>1246-1251</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>An API‐LC/MS/MS method was developed for the identification of the medicinal herb Podophyllum emodi based on the profile of its aryltetrahydronapthalene and related lignan marker compounds. This was done by matching the structural information from the tandem mass spectrometric data with those lignan marker compounds already reported for the herb. The method could be employed in the absence of reference standards for the markers and was particularly useful in view of the scarcity of supply of these chemical standards. It has been used successfully to differentiate Podophyllum emodi from two commonly used medicinal herbs of a different genus but having similar appearance, Radix clematidis and Radix gentiana, as well as a closely related herb, Podophyllum peltatum. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11114081</pmid><doi>10.1002/1096-9888(200011)35:11<1246::AID-JMS55>3.0.CO;2-L</doi><tpages>6</tpages></addata></record> |
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| subjects | API-LC/MS/MS Biological and medical sciences Biomarkers - analysis Biomarkers - chemistry Chromatography, High Pressure Liquid Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry General pharmacology Lignans - analysis Lignans - chemistry marker compound profile Mass Spectrometry - methods Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Plants, Toxic Podophyllotoxin - analogs & derivatives Podophyllotoxin - analysis Podophyllotoxin - chemistry Podophyllum - chemistry Podophyllum emodi Reference Standards Tetrahydronaphthalenes - analysis Tetrahydronaphthalenes - chemistry |
| title | Identification and characterization of Podophyllum emodi by API-LC/MS/MS |
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