Bullous Pemphigoid Associated with Silicosis
Bullous pemphigoid (BP) has never before been reported to associate with silicosis, although there are numerous reports of silicosis accompanied by different autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus, dermatomyositis or rheumatoid arthritis. We report on a 63-year...
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| Veröffentlicht in: | Dermatology (Basel) 2000-01, Vol.201 (3), p.265-267 |
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| container_title | Dermatology (Basel) |
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| creator | Ueki, H. Kohda, M. Hashimoto, T. Komai, A. Nobutoh, T. Yamaguchi, M. Ohmori, K. Miyashita, F. Yoda, N. |
| description | Bullous pemphigoid (BP) has never before been reported to associate with silicosis, although there are numerous reports of silicosis accompanied by different autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus, dermatomyositis or rheumatoid arthritis. We report on a 63-year-old Japanese patient with silicosis who developed tensed bullae, erosions and macular pigmentation on the trunk and extremities. Indirect immunofluorescence revealed anti-basement-membrane-zone antibodies; immunoblotting analysis demonstrated that the patient’s serum reacted with the 230-kD BP antigen in the epidermal extracts, as well as a recombinant protein of the NC16a domain of 180-kD BP antigen. Clinical symptoms improved after treatment with systemic steroids. To the best of our knowledge, this is the first reported case of BP associated with silicosis. |
| doi_str_mv | 10.1159/000018502 |
| format | Article |
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We report on a 63-year-old Japanese patient with silicosis who developed tensed bullae, erosions and macular pigmentation on the trunk and extremities. Indirect immunofluorescence revealed anti-basement-membrane-zone antibodies; immunoblotting analysis demonstrated that the patient’s serum reacted with the 230-kD BP antigen in the epidermal extracts, as well as a recombinant protein of the NC16a domain of 180-kD BP antigen. Clinical symptoms improved after treatment with systemic steroids. 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| source | Karger Journals; MEDLINE |
| subjects | Biological and medical sciences Bullous diseases of the skin Case Report Dermatology Humans Male Medical sciences Middle Aged Pemphigoid, Bullous - complications Pemphigoid, Bullous - pathology Silicosis - complications Silicosis - pathology Skin - pathology |
| title | Bullous Pemphigoid Associated with Silicosis |
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