Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison

Chloroquinoxaline sulfonamide (chlorosulfaquinoxaline, CQS, NSC 339004) is active against murine and human solid tumors. On the basis of its structural similarity to the topoisomerase IIbeta-specific drug XK469, CQS was tested and found to be both a topoisomerase-IIalpha and a topoisomerase-IIbeta p...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-11, Vol.60 (21), p.5937
Hauptverfasser:	Gao, H, Yamasaki, E F, Chan, K K, Shen, L L, Snapka, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm Antineoplastic Agents - pharmacology Cell Line DNA - metabolism DNA Topoisomerases, Type II DNA-Binding Proteins Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Guanidine - pharmacology Isoenzymes - antagonists & inhibitors Kidney - cytology Kidney - drug effects Kidney - enzymology Protein Denaturation Quinoxalines - pharmacology Sulfanilamides - pharmacology Topoisomerase II Inhibitors
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