Benign and Malignant Oncocytoma of the Salivary Glands with an Immunohistochemical Evaluation of Ki-67
We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells wa...
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| Veröffentlicht in: | O.R.L. Journal for oto-rhino-laryngology and its related specialties 2000-11, Vol.62 (6), p.338-341 |
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| container_title | O.R.L. Journal for oto-rhino-laryngology and its related specialties |
| container_volume | 62 |
| creator | Ito, Keiko Tsukuda, Mamoru Kawabe, Ryoichi Nakagawa, Chihiro Matsushita, Kazuhiko Kubota, Akira Furukawa, Madoka Kameda, Yoichi Ito, Takaaki |
| description | We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells was 3.3% in the benign oncocytomas and 6.5% in the malignant oncocytoma. The higher frequency of Ki-67-positive cells in the malignant oncocytoma might reflect active cell proliferation. Ki-67 immunostaining may be useful in distinguishing a benign oncocytoma from a malignant oncocytoma. |
| doi_str_mv | 10.1159/000027766 |
| format | Article |
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The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells was 3.3% in the benign oncocytomas and 6.5% in the malignant oncocytoma. The higher frequency of Ki-67-positive cells in the malignant oncocytoma might reflect active cell proliferation. Ki-67 immunostaining may be useful in distinguishing a benign oncocytoma from a malignant oncocytoma.</description><identifier>ISSN: 0301-1569</identifier><identifier>EISSN: 1423-0275</identifier><identifier>DOI: 10.1159/000027766</identifier><identifier>PMID: 11054019</identifier><identifier>CODEN: ORLJAH</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adenoma, Oxyphilic - chemistry ; Adenoma, Oxyphilic - diagnosis ; Adult ; Aged ; Biological and medical sciences ; Case Report ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemical methods ; Immunohistochemistry ; Immunological methods for diagnosis and exploration ; Immunopathology ; Ki-67 Antigen - analysis ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Prognosis ; Salivary Gland Neoplasms - chemistry ; Salivary Gland Neoplasms - diagnosis ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>O.R.L. Journal for oto-rhino-laryngology and its related specialties, 2000-11, Vol.62 (6), p.338-341</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright (c) 2000 S. 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Journal for oto-rhino-laryngology and its related specialties</title><addtitle>ORL</addtitle><description>We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells was 3.3% in the benign oncocytomas and 6.5% in the malignant oncocytoma. The higher frequency of Ki-67-positive cells in the malignant oncocytoma might reflect active cell proliferation. Ki-67 immunostaining may be useful in distinguishing a benign oncocytoma from a malignant oncocytoma.</description><subject>Adenoma, Oxyphilic - chemistry</subject><subject>Adenoma, Oxyphilic - diagnosis</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case Report</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemical methods</subject><subject>Immunohistochemistry</subject><subject>Immunological methods for diagnosis and exploration</subject><subject>Immunopathology</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Salivary Gland Neoplasms - chemistry</subject><subject>Salivary Gland Neoplasms - diagnosis</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0301-1569</issn><issn>1423-0275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0EFLHDEUB_Aglrq1PfRcKKGUQg9Tk5m8ZObYilVxZcHW8_Amk3GjM8mazFj89mbdxYViLkl4v7w8_oR85OwH51AdsbRypaTcIzMu8iJLN9gnM1YwnnGQ1QF5F-NtUpCX6i054JyBYLyake6XcfbGUXQtvcQ-HdGNdOG014-jH5D6jo5LQ_-k2gOGR3raJxrpPzsu0yN6PgyT80sbR6-XZrAae3rygP2Eo_Vu_frCZlK9J2867KP5sN0PyfXvk7_HZ9l8cXp-_HOe6aIUYyaNkK3iupJKGSgBTAuVbrDibVs1hZHQdNrkFTKlhVCIAlhXqgJ4A9CiLA7Jt03fVfD3k4ljPdioTZ-GNn6KtcoLBaWCBL_8B2_9FFyarc5zYIoJsUbfN0gHH2MwXb0Kdkgp1JzV6-Trl-ST_bxtODWDaXdyG3UCX7cAY0qpC-i0jTsHXIAUu8HuMNyY8FJfXM2fP6pXbZfQp1fRZpQniJCeDg</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Ito, Keiko</creator><creator>Tsukuda, Mamoru</creator><creator>Kawabe, Ryoichi</creator><creator>Nakagawa, Chihiro</creator><creator>Matsushita, Kazuhiko</creator><creator>Kubota, Akira</creator><creator>Furukawa, Madoka</creator><creator>Kameda, Yoichi</creator><creator>Ito, Takaaki</creator><general>Karger</general><general>S. 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Journal for oto-rhino-laryngology and its related specialties</jtitle><addtitle>ORL</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>62</volume><issue>6</issue><spage>338</spage><epage>341</epage><pages>338-341</pages><issn>0301-1569</issn><eissn>1423-0275</eissn><coden>ORLJAH</coden><abstract>We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells was 3.3% in the benign oncocytomas and 6.5% in the malignant oncocytoma. The higher frequency of Ki-67-positive cells in the malignant oncocytoma might reflect active cell proliferation. Ki-67 immunostaining may be useful in distinguishing a benign oncocytoma from a malignant oncocytoma.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11054019</pmid><doi>10.1159/000027766</doi><tpages>4</tpages></addata></record> |
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| ispartof | O.R.L. Journal for oto-rhino-laryngology and its related specialties, 2000-11, Vol.62 (6), p.338-341 |
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| language | eng |
| recordid | cdi_pubmed_primary_11054019 |
| source | MEDLINE; Karger Journals; Alma/SFX Local Collection; Karger:Jisc Collections:ORL, Ophthalmology, Dental Medicine, Obstetrics, Gynecology and Psychology, Psychiatry Archive Collection (2012-2112) |
| subjects | Adenoma, Oxyphilic - chemistry Adenoma, Oxyphilic - diagnosis Adult Aged Biological and medical sciences Case Report Diagnosis, Differential Female Humans Immunohistochemical methods Immunohistochemistry Immunological methods for diagnosis and exploration Immunopathology Ki-67 Antigen - analysis Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Prognosis Salivary Gland Neoplasms - chemistry Salivary Gland Neoplasms - diagnosis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Benign and Malignant Oncocytoma of the Salivary Glands with an Immunohistochemical Evaluation of Ki-67 |
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