Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil
The hepatobiliary distribution of 5-fluorouracil (5FU) catabolites was investigated in nine patients. Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detec...
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| Veröffentlicht in: | Magnetic resonance in medicine 2000-10, Vol.44 (4), p.516 |
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| creator | Dzik-Jurasz, A S Collins, D J Leach, M O Rowland, I J |
| description | The hepatobiliary distribution of 5-fluorouracil (5FU) catabolites was investigated in nine patients. Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients whose gallbladders were absent or abnormal. Signals from the gallbladder showed a 2.2-2.4 ppm high-frequency shift from alpha-fluoro-beta-alanine, suggesting the presence of alpha-fluoro-beta-alanine-bile-acid conjugates. 3D-chemical shift imaging of two patients receiving bolus 5FU revealed alpha-fluoro-beta-alanine to be localized to the liver within 1 hr of administration. In one patient examined 4 hr after bolus administration, catabolite signal was detected only in the gallbladder. |
| doi_str_mv | 10.1002/1522-2594(200010)44:4<516::AID-MRM3>3.0.CO;2-P |
| format | Article |
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Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients whose gallbladders were absent or abnormal. Signals from the gallbladder showed a 2.2-2.4 ppm high-frequency shift from alpha-fluoro-beta-alanine, suggesting the presence of alpha-fluoro-beta-alanine-bile-acid conjugates. 3D-chemical shift imaging of two patients receiving bolus 5FU revealed alpha-fluoro-beta-alanine to be localized to the liver within 1 hr of administration. 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Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients whose gallbladders were absent or abnormal. Signals from the gallbladder showed a 2.2-2.4 ppm high-frequency shift from alpha-fluoro-beta-alanine, suggesting the presence of alpha-fluoro-beta-alanine-bile-acid conjugates. 3D-chemical shift imaging of two patients receiving bolus 5FU revealed alpha-fluoro-beta-alanine to be localized to the liver within 1 hr of administration. In one patient examined 4 hr after bolus administration, catabolite signal was detected only in the gallbladder.</description><subject>Aged</subject><subject>Antimetabolites, Antineoplastic - administration & dosage</subject><subject>Antimetabolites, Antineoplastic - pharmacokinetics</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>beta-Alanine - analogs & derivatives</subject><subject>beta-Alanine - metabolism</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Fluorouracil - pharmacokinetics</subject><subject>Fluorouracil - therapeutic use</subject><subject>Gallbladder - metabolism</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><issn>0740-3194</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1OwkAYRWehEURfwcwSFoPf_LUWjQlBQRIIBnVNvnZmyJihbfpDomsf3Bp1dTfnntxcQiIOYw4grrkWggmdqKEAAA4jpSbqTvNoMpkuH9h6u5b3cgzj2eZWsOcT0odYAZM8UT1yXtfvXSlJYnVGepyD0Bp0n3wtMIQ0oDG2oqHIMPhPbHyR08LRIU9Gc7revtAMG0yL4BtLa7_PMdTU57TsSJs3Na1sZv3R53vaQW1NMTe0rIqmwqyxhh5tXrQ_DdfWnRoD1cyFtqiKtiN8uCCnrlPay78ckLf54-vsia02i-VsumIlF6JhgseJ65ZCDNoal6nIWJmkIlKRANSYSS5TMFZbdGlkUTsE4zSaOBI3qTByQK5-vWWbHqzZlZU_YPWx-79DfgOd4moZ</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Dzik-Jurasz, A S</creator><creator>Collins, D J</creator><creator>Leach, M O</creator><creator>Rowland, I J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200010</creationdate><title>Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil</title><author>Dzik-Jurasz, A S ; Collins, D J ; Leach, M O ; Rowland, I J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-2179fadd0705edfc46de39b264620a5ac313b0de5eafb6ea5fa0df5ad7628b2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Antimetabolites, Antineoplastic - administration & dosage</topic><topic>Antimetabolites, Antineoplastic - pharmacokinetics</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>beta-Alanine - analogs & derivatives</topic><topic>beta-Alanine - metabolism</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Fluorouracil - pharmacokinetics</topic><topic>Fluorouracil - therapeutic use</topic><topic>Gallbladder - metabolism</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dzik-Jurasz, A S</creatorcontrib><creatorcontrib>Collins, D J</creatorcontrib><creatorcontrib>Leach, M O</creatorcontrib><creatorcontrib>Rowland, I J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dzik-Jurasz, A S</au><au>Collins, D J</au><au>Leach, M O</au><au>Rowland, I J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2000-10</date><risdate>2000</risdate><volume>44</volume><issue>4</issue><spage>516</spage><pages>516-</pages><issn>0740-3194</issn><abstract>The hepatobiliary distribution of 5-fluorouracil (5FU) catabolites was investigated in nine patients. Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients whose gallbladders were absent or abnormal. Signals from the gallbladder showed a 2.2-2.4 ppm high-frequency shift from alpha-fluoro-beta-alanine, suggesting the presence of alpha-fluoro-beta-alanine-bile-acid conjugates. 3D-chemical shift imaging of two patients receiving bolus 5FU revealed alpha-fluoro-beta-alanine to be localized to the liver within 1 hr of administration. In one patient examined 4 hr after bolus administration, catabolite signal was detected only in the gallbladder.</abstract><cop>United States</cop><pmid>11025505</pmid><doi>10.1002/1522-2594(200010)44:4<516::AID-MRM3>3.0.CO;2-P</doi></addata></record> |
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| subjects | Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacokinetics Antimetabolites, Antineoplastic - therapeutic use beta-Alanine - analogs & derivatives beta-Alanine - metabolism Female Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Fluorouracil - therapeutic use Gallbladder - metabolism Humans Liver - metabolism Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male |
| title | Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil |
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