An additional phosphate-binding element in arrestin molecule. Implications for the mechanism of arrestin activation

Arrestins quench the signaling of a wide variety of G protein-coupled receptors by virtue of high-affinity binding to phosphorylated activated receptors. The high selectivity of arrestins for this particular functional form of receptor ensures their timely binding and dissociation. In a continuing e...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (52), p.41049
Hauptverfasser:	Vishnivetskiy, S A, Schubert, C, Climaco, G C, Gurevich, Y V, Velez, M G, Gurevich, V V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arrestin - chemistry Arrestin - metabolism Binding Sites Molecular Sequence Data Mutagenesis, Site-Directed Phosphates - metabolism Protein Structure, Secondary Structure-Activity Relationship
Online-Zugang:	Volltext
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