Differential activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in the liver and brain of rats : Implication for organ-specific carcinogenesis

Methyl methanesulfonate (MMS), a direct-acting alkylating agent, is a strong brain carcinogen but a poor hepatocarcinogen in rats. To elucidate the mechanism(s) leading to tissue-specific carcinogenesis in response to MMS, we compared the activation of the stress-activated protein kinases (SAPKs), t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-09, Vol.60 (18), p.5067-5073
Hauptverfasser:	YOUSIN SUH, UNG GU KANG, YONG SIK KIM, KIM, Woo-Ho, PARK, Sang-Chul, PARK, Joo-Bae
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 Alkylating Agents - toxicity Animals Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Brain - cytology Brain - drug effects Brain - enzymology Brain Neoplasms - chemically induced Brain Neoplasms - enzymology Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Cyclic AMP Response Element-Binding Protein - metabolism Enzyme Activation - drug effects Gene Expression Regulation - drug effects Isoenzymes - metabolism JNK Mitogen-Activated Protein Kinases Liver - cytology Liver - drug effects Liver - enzymology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - enzymology Male MAP Kinase Kinase 4 MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences Methyl Methanesulfonate - toxicity Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Organ Specificity p38 Mitogen-Activated Protein Kinases Proto-Oncogene Proteins c-jun - biosynthesis Rats Rats, Sprague-Dawley Transcription Factors - metabolism Tumors
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