Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1

Integrins alpha(1)beta(1) and alpha(2)beta(1) are two major collagen receptors on the surface of eukaryotic cells. Binding to collagen is primarily due to an A-domain near the N terminus of the alpha chains. Previously, we reported that recombinant A-domain of alpha(1)beta(1) (alpha(1)A) had at leas...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (50), p.38981
Hauptverfasser:	Xu, Y, Gurusiddappa, S, Rich, R L, Owens, R T, Keene, D R, Mayne, R, Höök, A, Höök, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Binding, Competitive Cattle Chickens Cloning, Molecular Collagen - chemistry Collagen - metabolism Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Gene Library Humans Integrin alpha1beta1 Integrins - metabolism Kinetics Microscopy, Electron Models, Biological Molecular Sequence Data Peptides - chemistry Protein Structure, Tertiary Receptors, Collagen Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sequence Homology, Amino Acid Surface Plasmon Resonance Time Factors
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