The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities

The initiation step of mucin-type O-glycosylation is controlled by a large family of homologous UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases). Differences in kinetic properties, substrate specificities, and expression patterns of these isoenzymes provide for differe...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (49), p.38197
Hauptverfasser:	Hassan, H, Reis, C A, Bennett, E P, Mirgorodskaya, E, Roepstorff, P, Hollingsworth, M A, Burchell, J, Taylor-Papadimitriou, J, Clausen, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Cell Line CHO Cells Cricetinae Glycopeptides - chemistry Glycopeptides - metabolism Glycosylation Isoenzymes - chemistry Isoenzymes - metabolism Kinetics Lectins - chemistry Molecular Sequence Data Mucin-1 - chemistry Mucin-1 - metabolism Mutagenesis, Site-Directed N-Acetylgalactosaminyltransferases - chemistry N-Acetylgalactosaminyltransferases - metabolism Peptide Fragments - chemistry Peptide Fragments - metabolism Polypeptide N-acetylgalactosaminyltransferase Recombinant Proteins - chemistry Recombinant Proteins - metabolism Substrate Specificity Transfection
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