Growth inhibition in G(1) and altered expression of cyclin D1 and p27(kip-1 )after forced connexin expression in lung and liver carcinoma cells

Gap junctional intercellular communication (GJIC) and connexin expression are frequently decreased in neoplasia and may contribute to defective growth control and loss of differentiated functions. GJIC, in E9 mouse lung carcinoma cells and WB-aB1 neoplastic rat liver epithelial cells, was elevated b...

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Veröffentlicht in:	Journal of cellular biochemistry 2000-09, Vol.79 (3), p.347
Hauptverfasser:	Koffler, L, Roshong, S, Kyu Park, I, Cesen-Cummings, K, Thompson, D C, Dwyer-Nield, L D, Rice, P, Mamay, C, Malkinson, A M, Ruch, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma - pathology Cell Communication Cell Cycle Proteins Cell Division Connexins - biosynthesis Connexins - genetics Connexins - physiology Cyclin D1 - biosynthesis Cyclin D1 - genetics Cyclin-Dependent Kinase Inhibitor p27 Cytokines - pharmacology Diffusion Fluorescent Dyes - metabolism G1 Phase - physiology Gap Junction beta-1 Protein Gap Junctions - physiology Gene Expression Regulation, Neoplastic - drug effects Liver Neoplasms, Experimental - pathology Lung Neoplasms - pathology Mice Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Nitric Oxide - biosynthesis Protein Kinases - biosynthesis Protein Kinases - genetics Rats Receptors, Growth Factor - biosynthesis Receptors, Growth Factor - genetics Recombinant Fusion Proteins - biosynthesis Transfection Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Suppressor Proteins
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