Estrogens as endogenous genotoxic agents--DNA adducts and mutations

Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to the role of estrogens in the induction of cancer, we examine formation of DNA adducts by reactive electrophilic estrogen metabolites, formation of reactive oxygen species...

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Veröffentlicht in:	Journal of the National Cancer Institute. Monographs 2000 (27), p.75
Hauptverfasser:	Cavalieri, E, Frenkel, K, Liehr, J G, Rogan, E, Roy, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA Adducts DNA Damage Estrogens - metabolism Estrogens, Catechol - metabolism Humans Mice Models, Biological Models, Chemical Mutation Neoplasms - genetics Neoplasms - metabolism Oxidants - physiology Purines - metabolism Reactive Oxygen Species - physiology
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