Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide

The transcription factor nuclear factor-kappaB (NF-kappaB) regulates genes important for tumor invasion, metastasis and chemoresistance. Normally, NF-kappaB remains sequestered in an inactive state by cytoplasmic inhibitor-of-kappaB (IkappaB) proteins. NF-kappaB translocates to nucleus and activates...

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Veröffentlicht in:	Oncogene 2000-08, Vol.19 (36), p.4159
Hauptverfasser:	Patel, N M, Nozaki, S, Shortle, N H, Bhat-Nakshatri, P, Newton, T R, Rice, S, Gelfanov, V, Boswell, S H, Goulet, Jr, R J, Sledge, Jr, G W, Nakshatri, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins Blotting, Northern Blotting, Western Breast Neoplasms - genetics Breast Neoplasms - metabolism Caenorhabditis elegans Proteins DNA - metabolism DNA-Binding Proteins - metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic Humans I-kappa B Proteins Inhibitor of Apoptosis Proteins NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism NF-KappaB Inhibitor alpha Paclitaxel - pharmacology Plants, Medicinal Protein Binding Proteins - metabolism Repressor Proteins - metabolism Sesquiterpenes - pharmacology Superoxide Dismutase - metabolism TNF Receptor-Associated Factor 1 Tumor Cells, Cultured
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