A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice

PBX1 is a proto-oncogene that plays important roles in pattern formation during development. It was discovered as a fusion with the E2A gene after chromosomal translocations in a subset of acute leukemias. The resulting E2a-Pbx1 chimeric proteins display potent oncogenic properties that appear to re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2000-09, Vol.96 (5), p.1906-1913
Hauptverfasser:	FELDMAN, B. J, HAMPTON, T, CLEARY, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal tumors. Experimental tumors Animals Animals, Newborn Base Sequence Biological and medical sciences Experimental malignant blood diseases Female Gene Deletion Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Lymphoma, T-Cell - etiology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - pathology Male Medical sciences Membrane Proteins - genetics Mice Mice, Transgenic Molecular Sequence Data Moloney murine leukemia virus - genetics Mutation Oncogene Proteins, Fusion - genetics Receptor, Notch1 Receptors, Cell Surface Retroviridae Infections - complications Retroviridae Infections - virology Survival Analysis Thymus Neoplasms - etiology Thymus Neoplasms - genetics Thymus Neoplasms - pathology Transcription Factors Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!