Afferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized rats
Department of Physiology, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil 04023-900 The role of baroreceptors, cardiopulmonary receptors, and renal nerves in the cardiovascular adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1% body wt, 0.4 ml/min) we...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-09, Vol.279 (3), p.884-R890 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 279 |
| creator | Colombari, Debora S. A Colombari, Eduardo Lopes, Oswaldo U Cravo, Sergio L |
| description | Department of Physiology, Universidade Federal de São
Paulo-Escola Paulista de Medicina, São Paulo, Brazil
04023-900
The role of baroreceptors,
cardiopulmonary receptors, and renal nerves in the cardiovascular
adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1%
body wt, 0.4 ml/min) were studied in urethan-anesthetized rats. In
control animals, VE produced a transitory increase in mean arterial
pressure (MAP), which peaked at 10 min (17 ± 4 mmHg) and
increases in renal (128 ± 6 and 169 ± 19% of baseline at
10 and 40 min, respectively) and hindlimb vascular conductance
(143 ± 6 and 150 ± 10%). These cardiovascular adjustments
to VE were unaffected by bilateral vagotomy. After sinoaortic
denervation, the increase in MAP induced by VE was greater than in
control rats (30 ± 4 mmHg). However, renal vasodilation in
response to VE was blocked, whereas hindlimb vasodilation was similar
to that observed in control rats. After unilateral renal denervation
(ipsilateral to flow recording), the initial renal vasodilation was
blocked. However, 40 min after VE, a significant renal vasodilation
(125 ± 4%) appeared. The hindlimb vasodilation and MAP responses
were unaffected by renal denervation. These results demonstrate that
the baroreceptor afferents are an essential component of cardiovascular
adjustments to VE, especially in the control of renal vascular
conductance. They also suggest that renal vasodilation induced by VE is
mediated by neural and hormonal mechanisms.
blood flow; cardiovascular afferents; baroreceptor afferents; renal
nerves |
| doi_str_mv | 10.1152/ajpregu.2000.279.3.R884 |
| format | Article |
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Paulo-Escola Paulista de Medicina, São Paulo, Brazil
04023-900
The role of baroreceptors,
cardiopulmonary receptors, and renal nerves in the cardiovascular
adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1%
body wt, 0.4 ml/min) were studied in urethan-anesthetized rats. In
control animals, VE produced a transitory increase in mean arterial
pressure (MAP), which peaked at 10 min (17 ± 4 mmHg) and
increases in renal (128 ± 6 and 169 ± 19% of baseline at
10 and 40 min, respectively) and hindlimb vascular conductance
(143 ± 6 and 150 ± 10%). These cardiovascular adjustments
to VE were unaffected by bilateral vagotomy. After sinoaortic
denervation, the increase in MAP induced by VE was greater than in
control rats (30 ± 4 mmHg). However, renal vasodilation in
response to VE was blocked, whereas hindlimb vasodilation was similar
to that observed in control rats. After unilateral renal denervation
(ipsilateral to flow recording), the initial renal vasodilation was
blocked. However, 40 min after VE, a significant renal vasodilation
(125 ± 4%) appeared. The hindlimb vasodilation and MAP responses
were unaffected by renal denervation. These results demonstrate that
the baroreceptor afferents are an essential component of cardiovascular
adjustments to VE, especially in the control of renal vascular
conductance. They also suggest that renal vasodilation induced by VE is
mediated by neural and hormonal mechanisms.
blood flow; cardiovascular afferents; baroreceptor afferents; renal
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Paulo-Escola Paulista de Medicina, São Paulo, Brazil
04023-900
The role of baroreceptors,
cardiopulmonary receptors, and renal nerves in the cardiovascular
adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1%
body wt, 0.4 ml/min) were studied in urethan-anesthetized rats. In
control animals, VE produced a transitory increase in mean arterial
pressure (MAP), which peaked at 10 min (17 ± 4 mmHg) and
increases in renal (128 ± 6 and 169 ± 19% of baseline at
10 and 40 min, respectively) and hindlimb vascular conductance
(143 ± 6 and 150 ± 10%). These cardiovascular adjustments
to VE were unaffected by bilateral vagotomy. After sinoaortic
denervation, the increase in MAP induced by VE was greater than in
control rats (30 ± 4 mmHg). However, renal vasodilation in
response to VE was blocked, whereas hindlimb vasodilation was similar
to that observed in control rats. After unilateral renal denervation
(ipsilateral to flow recording), the initial renal vasodilation was
blocked. However, 40 min after VE, a significant renal vasodilation
(125 ± 4%) appeared. The hindlimb vasodilation and MAP responses
were unaffected by renal denervation. These results demonstrate that
the baroreceptor afferents are an essential component of cardiovascular
adjustments to VE, especially in the control of renal vascular
conductance. They also suggest that renal vasodilation induced by VE is
mediated by neural and hormonal mechanisms.
blood flow; cardiovascular afferents; baroreceptor afferents; renal
nerves</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Aorta - innervation</subject><subject>Aorta - physiology</subject><subject>Blood Pressure - physiology</subject><subject>Blood Volume - physiology</subject><subject>Heart Rate - physiology</subject><subject>Kidney - blood supply</subject><subject>Kidney - innervation</subject><subject>Male</subject><subject>Neurons, Afferent - physiology</subject><subject>Pressoreceptors - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal Artery - innervation</subject><subject>Renal Artery - physiology</subject><subject>Renal Circulation - physiology</subject><subject>Space life sciences</subject><subject>Vagotomy</subject><subject>Vasodilation - physiology</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP4zAUhS3EiJYOfwGyYpfgRx71EiFgkJCQRsza49jXTaq8sGNK-PXjqOWxmZUX9zvHRx9CFwQnhGT0Sm4HCxufUIxxQguesOT3ep0eoWW40pikHB-jJWY5i3NC-AKdOrcNbMpSdoIWBPMsp2m2RH-vjQEL3RgNcqx2cnJR3UVKWl33r9Ip30gbSb31bmwDNV-1V6Cjcope-8a3EMHbIDtX992clB24sYKxfg-MlaP7iX4Y2Tg4O7wr9Ofu9vnmV_z4dP9wc_0YK8aLMdZ5WWqtMljLDMDQgmEow8KcE64UpmUG3AAuc84okWCYkWqNeRouXOOCshW63PcOtn_xYYRoa6egacKi3jtRUIrTvCABLPagsr1zFowYbN1KOwmCxSxXHOSKWa4IcgUTs9yQPD984csW9Lfc3mYA-B6o6k21qy2IoZqCmabfTOLON80zvI0f9V_FYtAmZOP_Zz8XfY35B5VRoHc</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Colombari, Debora S. A</creator><creator>Colombari, Eduardo</creator><creator>Lopes, Oswaldo U</creator><creator>Cravo, Sergio L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Afferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized rats</title><author>Colombari, Debora S. A ; Colombari, Eduardo ; Lopes, Oswaldo U ; Cravo, Sergio L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-d6bbddc5e8a5eef2730eb2456919cc02b5e9fe0b69321aef3fac809402b9d0723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Aorta - innervation</topic><topic>Aorta - physiology</topic><topic>Blood Pressure - physiology</topic><topic>Blood Volume - physiology</topic><topic>Heart Rate - physiology</topic><topic>Kidney - blood supply</topic><topic>Kidney - innervation</topic><topic>Male</topic><topic>Neurons, Afferent - physiology</topic><topic>Pressoreceptors - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal Artery - innervation</topic><topic>Renal Artery - physiology</topic><topic>Renal Circulation - physiology</topic><topic>Space life sciences</topic><topic>Vagotomy</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colombari, Debora S. A</creatorcontrib><creatorcontrib>Colombari, Eduardo</creatorcontrib><creatorcontrib>Lopes, Oswaldo U</creatorcontrib><creatorcontrib>Cravo, Sergio L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colombari, Debora S. A</au><au>Colombari, Eduardo</au><au>Lopes, Oswaldo U</au><au>Cravo, Sergio L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Afferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized rats</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>279</volume><issue>3</issue><spage>884</spage><epage>R890</epage><pages>884-R890</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>Department of Physiology, Universidade Federal de São
Paulo-Escola Paulista de Medicina, São Paulo, Brazil
04023-900
The role of baroreceptors,
cardiopulmonary receptors, and renal nerves in the cardiovascular
adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1%
body wt, 0.4 ml/min) were studied in urethan-anesthetized rats. In
control animals, VE produced a transitory increase in mean arterial
pressure (MAP), which peaked at 10 min (17 ± 4 mmHg) and
increases in renal (128 ± 6 and 169 ± 19% of baseline at
10 and 40 min, respectively) and hindlimb vascular conductance
(143 ± 6 and 150 ± 10%). These cardiovascular adjustments
to VE were unaffected by bilateral vagotomy. After sinoaortic
denervation, the increase in MAP induced by VE was greater than in
control rats (30 ± 4 mmHg). However, renal vasodilation in
response to VE was blocked, whereas hindlimb vasodilation was similar
to that observed in control rats. After unilateral renal denervation
(ipsilateral to flow recording), the initial renal vasodilation was
blocked. However, 40 min after VE, a significant renal vasodilation
(125 ± 4%) appeared. The hindlimb vasodilation and MAP responses
were unaffected by renal denervation. These results demonstrate that
the baroreceptor afferents are an essential component of cardiovascular
adjustments to VE, especially in the control of renal vascular
conductance. They also suggest that renal vasodilation induced by VE is
mediated by neural and hormonal mechanisms.
blood flow; cardiovascular afferents; baroreceptor afferents; renal
nerves</abstract><cop>United States</cop><pmid>10956245</pmid><doi>10.1152/ajpregu.2000.279.3.R884</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0363-6119 |
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| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Anesthesia Animals Aorta - innervation Aorta - physiology Blood Pressure - physiology Blood Volume - physiology Heart Rate - physiology Kidney - blood supply Kidney - innervation Male Neurons, Afferent - physiology Pressoreceptors - physiology Rats Rats, Wistar Renal Artery - innervation Renal Artery - physiology Renal Circulation - physiology Space life sciences Vagotomy Vasodilation - physiology |
| title | Afferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized rats |
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