Nociception in Cyclooxygenase Isozyme-Deficient Mice

Prostaglandins formed by cyclooxygenase-1 (COX-1) or COX-2 produce hyperalgesia in sensory nerve endings. To assess the relative roles of the two enzymes in pain processing, we compared responses of COX-1- or COX-2-deficient homozygous and heterozygous mice with wild-type controls in the hot plate a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-08, Vol.97 (18), p.10272-10276
Hauptverfasser:	Ballou, L R, Botting, R M, Goorha, S, Zhang, J, Vane, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Behavior, Animal Biochemistry Biological Sciences Crosses, Genetic Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase inhibitors Enzymes Female Female animals Genetics Heterozygotes Homozygote Hot Temperature Isoenzymes - deficiency Isoenzymes - genetics Isoenzymes - metabolism Male Male animals Membrane Proteins Messenger RNA Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Pain Pain - genetics Pain - physiopathology Pharmacology Prostaglandin-Endoperoxide Synthases - deficiency Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Reaction Time Reverse Transcriptase Polymerase Chain Reaction Rodents Sex Characteristics Spinal cord
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