Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders
Summary We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombo...
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| Veröffentlicht in: | Clinical and laboratory haematology 2000-06, Vol.22 (3), p.175-178 |
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| container_title | Clinical and laboratory haematology |
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| creator | Leach, M. Parsons, R.M. Reilly, J.T. Winfield, D.A. |
| description | Summary
We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re‐exposure to the drug when his disease had become refractory to all other treatments. A retrospective review of the case notes of 45 patients with lymphoproliferative disorders treated with fludarabine over the past 6 years indicated the development of autoimmune thrombocytopenia in 4.5% (two out of 45) and autoimmune haemolytic anaemia in 6.7% (three of the 45). |
| doi_str_mv | 10.1046/j.1365-2257.2000.00305.x |
| format | Article |
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We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re‐exposure to the drug when his disease had become refractory to all other treatments. A retrospective review of the case notes of 45 patients with lymphoproliferative disorders treated with fludarabine over the past 6 years indicated the development of autoimmune thrombocytopenia in 4.5% (two out of 45) and autoimmune haemolytic anaemia in 6.7% (three of the 45).</description><identifier>ISSN: 0141-9854</identifier><identifier>EISSN: 1365-2257</identifier><identifier>DOI: 10.1046/j.1365-2257.2000.00305.x</identifier><identifier>PMID: 10931169</identifier><identifier>CODEN: CLHAD3</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Anemia, Hemolytic - chemically induced ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Autoimmune thrombocytopenia ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; fludarbine ; Humans ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - therapeutic use ; Leukemia, Lymphocytic, Chronic, B-Cell - complications ; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy ; lymphoproliferative disorders ; Lymphoproliferative Disorders - complications ; Lymphoproliferative Disorders - drug therapy ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Purpura, Thrombocytopenic, Idiopathic - chemically induced ; Toxicity: blood ; Vidarabine - adverse effects ; Vidarabine - analogs & derivatives ; Vidarabine - therapeutic use</subject><ispartof>Clinical and laboratory haematology, 2000-06, Vol.22 (3), p.175-178</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3835-341f61f9cd5e47bac897e62f17f08b998a5dd1534e0089627d3df6c3916574f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2257.2000.00305.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2257.2000.00305.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1427325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10931169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leach, M.</creatorcontrib><creatorcontrib>Parsons, R.M.</creatorcontrib><creatorcontrib>Reilly, J.T.</creatorcontrib><creatorcontrib>Winfield, D.A.</creatorcontrib><title>Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders</title><title>Clinical and laboratory haematology</title><addtitle>Clin Lab Haematol</addtitle><description>Summary
We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re‐exposure to the drug when his disease had become refractory to all other treatments. A retrospective review of the case notes of 45 patients with lymphoproliferative disorders treated with fludarabine over the past 6 years indicated the development of autoimmune thrombocytopenia in 4.5% (two out of 45) and autoimmune haemolytic anaemia in 6.7% (three of the 45).</description><subject>Adult</subject><subject>Aged</subject><subject>Anemia, Hemolytic - chemically induced</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Autoimmune thrombocytopenia</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>fludarbine</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - complications</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</subject><subject>lymphoproliferative disorders</subject><subject>Lymphoproliferative Disorders - complications</subject><subject>Lymphoproliferative Disorders - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Purpura, Thrombocytopenic, Idiopathic - chemically induced</subject><subject>Toxicity: blood</subject><subject>Vidarabine - adverse effects</subject><subject>Vidarabine - analogs & derivatives</subject><subject>Vidarabine - therapeutic use</subject><issn>0141-9854</issn><issn>1365-2257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1L5DAUhoMoOqv7FyQX3rabNF-N4MUgrroMCn4g7E1I84EZ26aknXX67-04rnp1Duc874HzAAAxyjGi_Ncyx4SzrCiYyAuEUI4QQSxf74DZ52IXzBCmOJMlowfgR98vEcIEC7EPDjCSBGMuZ8DMV0MMTbNqHRyeU2yqaMYhdq4N-hTOoYlNVwejhxBbGD309crqpKvwzrukuxGGFtZj0z3HLsU6-Gk4hH8O2tDHZF3qj8Ce13Xvfn7UQ_D4--Lh_Cpb3F5en88XmSElYRmh2HPspbHMUVFpU0rheOGx8KispCw1sxYzQh1CpeSFsMR6bojEnAnqBTkEx9u73apqnFVdCo1Oo_r_7QScfAC6N7r2Sbcm9F8cLQQp2ISdbbHXULvx2xm1ka-WauNYbRyrjXz1Ll-t1fWfxdXUTflsmw_94NafeZ1eFBdEMPV0c6n-4vs7RO6oWpA3vgyIZw</recordid><startdate>200006</startdate><enddate>200006</enddate><creator>Leach, M.</creator><creator>Parsons, R.M.</creator><creator>Reilly, J.T.</creator><creator>Winfield, D.A.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200006</creationdate><title>Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders</title><author>Leach, M. ; Parsons, R.M. ; Reilly, J.T. ; Winfield, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3835-341f61f9cd5e47bac897e62f17f08b998a5dd1534e0089627d3df6c3916574f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anemia, Hemolytic - chemically induced</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Autoimmune thrombocytopenia</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>fludarbine</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - complications</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</topic><topic>lymphoproliferative disorders</topic><topic>Lymphoproliferative Disorders - complications</topic><topic>Lymphoproliferative Disorders - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Purpura, Thrombocytopenic, Idiopathic - chemically induced</topic><topic>Toxicity: blood</topic><topic>Vidarabine - adverse effects</topic><topic>Vidarabine - analogs & derivatives</topic><topic>Vidarabine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leach, M.</creatorcontrib><creatorcontrib>Parsons, R.M.</creatorcontrib><creatorcontrib>Reilly, J.T.</creatorcontrib><creatorcontrib>Winfield, D.A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Clinical and laboratory haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leach, M.</au><au>Parsons, R.M.</au><au>Reilly, J.T.</au><au>Winfield, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders</atitle><jtitle>Clinical and laboratory haematology</jtitle><addtitle>Clin Lab Haematol</addtitle><date>2000-06</date><risdate>2000</risdate><volume>22</volume><issue>3</issue><spage>175</spage><epage>178</epage><pages>175-178</pages><issn>0141-9854</issn><eissn>1365-2257</eissn><coden>CLHAD3</coden><abstract>Summary
We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re‐exposure to the drug when his disease had become refractory to all other treatments. A retrospective review of the case notes of 45 patients with lymphoproliferative disorders treated with fludarabine over the past 6 years indicated the development of autoimmune thrombocytopenia in 4.5% (two out of 45) and autoimmune haemolytic anaemia in 6.7% (three of the 45).</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10931169</pmid><doi>10.1046/j.1365-2257.2000.00305.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Anemia, Hemolytic - chemically induced Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Autoimmune thrombocytopenia Biological and medical sciences Drug toxicity and drugs side effects treatment fludarbine Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy lymphoproliferative disorders Lymphoproliferative Disorders - complications Lymphoproliferative Disorders - drug therapy Male Medical sciences Pharmacology. Drug treatments Purpura, Thrombocytopenic, Idiopathic - chemically induced Toxicity: blood Vidarabine - adverse effects Vidarabine - analogs & derivatives Vidarabine - therapeutic use |
| title | Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders |
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