Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements
Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with...
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| Veröffentlicht in: | Artificial cells, blood substitutes, and immobilization biotechnology blood substitutes, and immobilization biotechnology, 2000-01, Vol.28 (4), p.293-305 |
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| container_title | Artificial cells, blood substitutes, and immobilization biotechnology |
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| creator | Capuani, G. Miccheli, A. Tomassini, A. Falasca, L. Aureli, T. Conti, F. |
| description | Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information from the intact system. |
| doi_str_mv | 10.3109/10731190009119360 |
| format | Article |
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Psychology ; Gels ; hepatocytes ; Hepatocytes - cytology ; Immobilization of organelles and whole cells ; Immobilization techniques ; Liver, Artificial ; Living systems studies ; Magnetic Resonance Imaging ; Mathematical models ; Methods. Procedures. 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The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information from the intact system.</description><subject>alginate</subject><subject>Alginates</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell Count</subject><subject>Cell Size</subject><subject>Cells, Immobilized - cytology</subject><subject>Cytological Techniques - methods</subject><subject>Cytology</subject><subject>Diffusion</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gels</subject><subject>hepatocytes</subject><subject>Hepatocytes - cytology</subject><subject>Immobilization of organelles and whole cells</subject><subject>Immobilization techniques</subject><subject>Liver, Artificial</subject><subject>Living systems studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Mathematical models</subject><subject>Methods. Procedures. Technologies</subject><subject>Noninvasive medical procedures</subject><subject>Rats</subject><subject>Tissue</subject><subject>Water</subject><subject>Water - metabolism</subject><subject>water diffusion</subject><issn>1073-1199</issn><issn>1532-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSdI0P6CX4kPJzY3GktcS7SUs_QikBEJzDGZWHnUdZMuV5JT999WyG9ISSE_6mOcZNK8Yewv8gwCuz4A3AkBzznVexIK_YEdQi6qUoOTLvM_1Mlf0IXsd413mhITqgB1muVIN50fsdknOzQ5Dce_dPFDRUaIw9COm3o-FtwW6n9sTlTSmgNNEXbGmCZM3m0SxWG2K79cXRddbO8etMhDGOdCQ8fiGvbLoIp3s12N28-Xzj-W38vLq68Xy_LI0Na9TaaQgQUYqw0XTcKqsMrSSnQZSulMGrBHYWFDGaruSIGsjF7qulYKO50txzE53fafgf80UUzv00eTJcCQ_x7aBquYL3fwXrECKnOYWhB1ogo8xkG2n0A8YNi3wdht--yT87LzbN59XA3V_Gbu0M_B-D2A06GzA0fTxkZNSQL3I2Kcd1o_WhwF_--C6NuHG-fDgiOee8fEffU3o0tpgoPbOz2HMH_HMEH8A0r2yNg</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Capuani, G.</creator><creator>Miccheli, A.</creator><creator>Tomassini, A.</creator><creator>Falasca, L.</creator><creator>Aureli, T.</creator><creator>Conti, F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements</title><author>Capuani, G. ; Miccheli, A. ; Tomassini, A. ; Falasca, L. ; Aureli, T. ; Conti, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-c43e3ec48c03770e2f8ceb4d91e89d8c1fc3a7f18cf9fb4145c46955881d08cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>alginate</topic><topic>Alginates</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cell Count</topic><topic>Cell Size</topic><topic>Cells, Immobilized - cytology</topic><topic>Cytological Techniques - methods</topic><topic>Cytology</topic><topic>Diffusion</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gels</topic><topic>hepatocytes</topic><topic>Hepatocytes - cytology</topic><topic>Immobilization of organelles and whole cells</topic><topic>Immobilization techniques</topic><topic>Liver, Artificial</topic><topic>Living systems studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Mathematical models</topic><topic>Methods. Procedures. Technologies</topic><topic>Noninvasive medical procedures</topic><topic>Rats</topic><topic>Tissue</topic><topic>Water</topic><topic>Water - metabolism</topic><topic>water diffusion</topic><toplevel>online_resources</toplevel><creatorcontrib>Capuani, G.</creatorcontrib><creatorcontrib>Miccheli, A.</creatorcontrib><creatorcontrib>Tomassini, A.</creatorcontrib><creatorcontrib>Falasca, L.</creatorcontrib><creatorcontrib>Aureli, T.</creatorcontrib><creatorcontrib>Conti, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial cells, blood substitutes, and immobilization biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capuani, G.</au><au>Miccheli, A.</au><au>Tomassini, A.</au><au>Falasca, L.</au><au>Aureli, T.</au><au>Conti, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements</atitle><jtitle>Artificial cells, blood substitutes, and immobilization biotechnology</jtitle><addtitle>Artif Cells Blood Substit Immobil Biotechnol</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>28</volume><issue>4</issue><spage>293</spage><epage>305</epage><pages>293-305</pages><issn>1073-1199</issn><eissn>1532-4184</eissn><coden>ABSBE4</coden><abstract>Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). 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| identifier | ISSN: 1073-1199 |
| ispartof | Artificial cells, blood substitutes, and immobilization biotechnology, 2000-01, Vol.28 (4), p.293-305 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | alginate Alginates Animals Biological and medical sciences Biotechnology Cell Count Cell Size Cells, Immobilized - cytology Cytological Techniques - methods Cytology Diffusion Fundamental and applied biological sciences. Psychology Gels hepatocytes Hepatocytes - cytology Immobilization of organelles and whole cells Immobilization techniques Liver, Artificial Living systems studies Magnetic Resonance Imaging Mathematical models Methods. Procedures. Technologies Noninvasive medical procedures Rats Tissue Water Water - metabolism water diffusion |
| title | Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements |
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