Molecular and Pharmacokinetic Properties Associated with the Therapeutics of Bcl-2 Antisense Oligonucleotide G3139 Combined with Free and Liposomal Doxorubicin

Bcl-2 is a key apoptosis-regulating protein that has been implicated in mechanisms of chemoresistance for a variety of malignancies by blocking programmed cell death. This study investigated the activity of the Bcl-2 antisense oligodeoxynucleotide (AS ODN) G3139 combined with free doxorubicin (F-DOX...

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Veröffentlicht in:	Clinical cancer research 2000-07, Vol.6 (7), p.2891-2902
Hauptverfasser:	LOPES DE MENEZES, D. E, HUDON, N, MCINTOSH, N, MAYER, L. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Biological and medical sciences Breast Neoplasms - drug therapy Cell Division - drug effects Chemotherapy Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Doxorubicin - toxicity Drug Carriers Female Genes, bcl-2 Humans Liposomes Medical sciences Mice Mice, SCID Oligonucleotides, Antisense - pharmacokinetics Oligonucleotides, Antisense - therapeutic use Oligonucleotides, Antisense - toxicity Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - analysis Thionucleotides - pharmacokinetics Thionucleotides - therapeutic use Thionucleotides - toxicity Tumor Cells, Cultured Xenograft Model Antitumor Assays
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