Cordycepin: Selective Growth Inhibitor Derived from Liquid Culture of Cordyceps militaris against Clostridium spp
The growth responses of nine human intestinal bacteria to liquid culture of Cordyceps militaris Link. Pt. (Ascomycotina: Clavicipitaceae) collected from a pupa of Bombyx mori L. (Lepidoptera: Bombycidae) were examined using spectrophotometric and impregnated paper disk methods and compared to those...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2000-07, Vol.48 (7), p.2744-2748 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | AHN, Young-Joon PARK, Suck-Joon LEE, Sang-Gil SHIN, Sang-Cheol CHOI, Don-Ha |
| description | The growth responses of nine human intestinal bacteria to liquid culture of Cordyceps militaris Link. Pt. (Ascomycotina: Clavicipitaceae) collected from a pupa of Bombyx mori L. (Lepidoptera: Bombycidae) were examined using spectrophotometric and impregnated paper disk methods and compared to those of tetracycline and chloramphenicol, as well as those of Coptis japonica root-derived berberine chloride. The biologically active constituent of the cultures was characterized as cordycepin (3'-deoxyadenosine) by spectroscopic analysis. This compound revealed potent growth-inhibiting activity toward Clostridium paraputrificum and Clostridium perfringens at 10 microgram/disk without adverse effects on the growth of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium adolescentis, Lactobacillus acidophilus, and Lactobacillus casei, whereas tetracycline and chloramphenicol inhibited the growth of these lactic acid-producing bacteria, clostridia and Escherichia coli. However, C. militaris-derived materials revealed no growth stimulation on the bifidobacteria and lactobacilli. These results may be an indication of at least one of the pharmacological actions of C. militaris. As a naturally occurring antibacterial agent, cordycepin could be useful as a new preventive agent against various diseases caused by clostridia. |
| doi_str_mv | 10.1021/jf990862n |
| format | Article |
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Pt. (Ascomycotina: Clavicipitaceae) collected from a pupa of Bombyx mori L. (Lepidoptera: Bombycidae) were examined using spectrophotometric and impregnated paper disk methods and compared to those of tetracycline and chloramphenicol, as well as those of Coptis japonica root-derived berberine chloride. The biologically active constituent of the cultures was characterized as cordycepin (3'-deoxyadenosine) by spectroscopic analysis. This compound revealed potent growth-inhibiting activity toward Clostridium paraputrificum and Clostridium perfringens at 10 microgram/disk without adverse effects on the growth of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium adolescentis, Lactobacillus acidophilus, and Lactobacillus casei, whereas tetracycline and chloramphenicol inhibited the growth of these lactic acid-producing bacteria, clostridia and Escherichia coli. However, C. militaris-derived materials revealed no growth stimulation on the bifidobacteria and lactobacilli. These results may be an indication of at least one of the pharmacological actions of C. militaris. As a naturally occurring antibacterial agent, cordycepin could be useful as a new preventive agent against various diseases caused by clostridia.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf990862n</identifier><identifier>PMID: 10898616</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animal, plant and microbial ecology ; Animals ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Biological and medical sciences ; Bombyx - microbiology ; Clostridium - drug effects ; Deoxyadenosines - pharmacology ; Fundamental and applied biological sciences. Psychology ; Growth Inhibitors - pharmacology ; Humans ; Hypocreales - chemistry ; Intestines - microbiology ; Microbial ecology ; Microbiology ; Normal microflora of man and animals. Rumen</subject><ispartof>Journal of agricultural and food chemistry, 2000-07, Vol.48 (7), p.2744-2748</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1470825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10898616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AHN, Young-Joon</creatorcontrib><creatorcontrib>PARK, Suck-Joon</creatorcontrib><creatorcontrib>LEE, Sang-Gil</creatorcontrib><creatorcontrib>SHIN, Sang-Cheol</creatorcontrib><creatorcontrib>CHOI, Don-Ha</creatorcontrib><title>Cordycepin: Selective Growth Inhibitor Derived from Liquid Culture of Cordyceps militaris against Clostridium spp</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The growth responses of nine human intestinal bacteria to liquid culture of Cordyceps militaris Link. Pt. (Ascomycotina: Clavicipitaceae) collected from a pupa of Bombyx mori L. (Lepidoptera: Bombycidae) were examined using spectrophotometric and impregnated paper disk methods and compared to those of tetracycline and chloramphenicol, as well as those of Coptis japonica root-derived berberine chloride. The biologically active constituent of the cultures was characterized as cordycepin (3'-deoxyadenosine) by spectroscopic analysis. This compound revealed potent growth-inhibiting activity toward Clostridium paraputrificum and Clostridium perfringens at 10 microgram/disk without adverse effects on the growth of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium adolescentis, Lactobacillus acidophilus, and Lactobacillus casei, whereas tetracycline and chloramphenicol inhibited the growth of these lactic acid-producing bacteria, clostridia and Escherichia coli. However, C. militaris-derived materials revealed no growth stimulation on the bifidobacteria and lactobacilli. These results may be an indication of at least one of the pharmacological actions of C. militaris. As a naturally occurring antibacterial agent, cordycepin could be useful as a new preventive agent against various diseases caused by clostridia.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Bombyx - microbiology</subject><subject>Clostridium - drug effects</subject><subject>Deoxyadenosines - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Hypocreales - chemistry</subject><subject>Intestines - microbiology</subject><subject>Microbial ecology</subject><subject>Microbiology</subject><subject>Normal microflora of man and animals. Rumen</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz7tOwzAYBWALgaAUBl4AeWAN2HF8Y4MUSlElkCgLS-TGNhhyw3aAbqy8Jk9CpRaYfumcT0f6ATjA6BijFJ88WymRYGmzAQaYpiihGItNMEDLMhGU4R2wG8IzQkhQjrbBDkZCCobZAMS89XpRms41p9-fX_DOVKaM7s3AsW_f4xOcNE9u7mLr4cj4Za6h9W0Np-61dxrmfRV7b2Br4e9QgLWrXFTeBagelWtChHnVhuiddn0NQ9ftgS2rqmD213cI7i8vZvlVMr0ZT_KzaeJIhmIisnlmNZ5LqTJLKSaWcSVSSVKb2pJzLhhjWBKdkUxRwymRmmCjrcmUIESRIThc7Xb9vDa66LyrlV8Uv-8vwdEaqFCqynrVlC78u4wjkdIlS1bMhWg-_mrlXwrGCafF7PauyB9GVJ6Pr4sr8gPEZ3nW</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>AHN, Young-Joon</creator><creator>PARK, Suck-Joon</creator><creator>LEE, Sang-Gil</creator><creator>SHIN, Sang-Cheol</creator><creator>CHOI, Don-Ha</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000701</creationdate><title>Cordycepin: Selective Growth Inhibitor Derived from Liquid Culture of Cordyceps militaris against Clostridium spp</title><author>AHN, Young-Joon ; PARK, Suck-Joon ; LEE, Sang-Gil ; SHIN, Sang-Cheol ; CHOI, Don-Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i340t-84b4fd1b99a4f5513f67a82932f2fc7778666193d434a5e7539d31edfe4a833a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Bombyx - microbiology</topic><topic>Clostridium - drug effects</topic><topic>Deoxyadenosines - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Hypocreales - chemistry</topic><topic>Intestines - microbiology</topic><topic>Microbial ecology</topic><topic>Microbiology</topic><topic>Normal microflora of man and animals. Rumen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AHN, Young-Joon</creatorcontrib><creatorcontrib>PARK, Suck-Joon</creatorcontrib><creatorcontrib>LEE, Sang-Gil</creatorcontrib><creatorcontrib>SHIN, Sang-Cheol</creatorcontrib><creatorcontrib>CHOI, Don-Ha</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AHN, Young-Joon</au><au>PARK, Suck-Joon</au><au>LEE, Sang-Gil</au><au>SHIN, Sang-Cheol</au><au>CHOI, Don-Ha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cordycepin: Selective Growth Inhibitor Derived from Liquid Culture of Cordyceps militaris against Clostridium spp</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>48</volume><issue>7</issue><spage>2744</spage><epage>2748</epage><pages>2744-2748</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>The growth responses of nine human intestinal bacteria to liquid culture of Cordyceps militaris Link. Pt. (Ascomycotina: Clavicipitaceae) collected from a pupa of Bombyx mori L. (Lepidoptera: Bombycidae) were examined using spectrophotometric and impregnated paper disk methods and compared to those of tetracycline and chloramphenicol, as well as those of Coptis japonica root-derived berberine chloride. The biologically active constituent of the cultures was characterized as cordycepin (3'-deoxyadenosine) by spectroscopic analysis. This compound revealed potent growth-inhibiting activity toward Clostridium paraputrificum and Clostridium perfringens at 10 microgram/disk without adverse effects on the growth of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium adolescentis, Lactobacillus acidophilus, and Lactobacillus casei, whereas tetracycline and chloramphenicol inhibited the growth of these lactic acid-producing bacteria, clostridia and Escherichia coli. However, C. militaris-derived materials revealed no growth stimulation on the bifidobacteria and lactobacilli. These results may be an indication of at least one of the pharmacological actions of C. militaris. As a naturally occurring antibacterial agent, cordycepin could be useful as a new preventive agent against various diseases caused by clostridia.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>10898616</pmid><doi>10.1021/jf990862n</doi><tpages>5</tpages></addata></record> |
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| subjects | Animal, plant and microbial ecology Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Bombyx - microbiology Clostridium - drug effects Deoxyadenosines - pharmacology Fundamental and applied biological sciences. Psychology Growth Inhibitors - pharmacology Humans Hypocreales - chemistry Intestines - microbiology Microbial ecology Microbiology Normal microflora of man and animals. Rumen |
| title | Cordycepin: Selective Growth Inhibitor Derived from Liquid Culture of Cordyceps militaris against Clostridium spp |
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