Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines

Expression of MET, the receptor for hepatocyte growth factor (HGF), has been associated with androgen-insensitive prostate cancer. In this study we evaluated MET activation by HGF and HGF action in prostate cancer cell lines. HGF causes phosphorylation (activation) of the MET receptor in three andro...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2000-07, Vol.141 (7), p.2567
Hauptverfasser:	Qadan, L R, Perez-Stable, C M, Schwall, R H, Burnstein, K L, Ostenson, R C, Howard, G A, Roos, B A
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - physiology Cell Cycle - drug effects Cell Division - drug effects Drug Resistance Drug Synergism Hepatocyte Growth Factor - pharmacology Humans Male Phosphorylation Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism RNA, Messenger - metabolism Tumor Cells, Cultured Tyrosine - metabolism Vitamin D - analogs & derivatives Vitamin D - pharmacology
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