Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase

The tetrameric form of native serum-derived bovine acetylcholinesterase is retained in the circulation for much longer periods (mean residence time, MRT = 1390 min) than recombinant bovine acetylcholinesterase (rBoAChE) produced in the HEK-293 cell system (MRT = 57 min). Extensive matrix-assisted la...

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Veröffentlicht in:	The Journal of biological chemistry 2000-09, Vol.275 (38), p.29488
Hauptverfasser:	Kronman, C, Chitlaru, T, Elhanany, E, Velan, B, Shafferman, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - blood Acetylcholinesterase - genetics Acetylcholinesterase - pharmacokinetics Animals Cattle Cell Line Dimerization Glycoproteins - blood Humans N-Acetylneuraminic Acid Protein Processing, Post-Translational
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