13-week subchronic oral toxicity study of ammonium sulfate in rats
A 13-week subchronic oral toxicity study of ammonium sulfate was performed in both sexes of F344 rats by feeding them a CRF-1 powder diet containing concentrations of 0%, 0.38%, 0.75%, 1.5%, and 3.0% of the substance. Rats were randomly divided into 5 groups each consisting of 10 males and 10 female...
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| Veröffentlicht in: | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 1999 (117), p.108 |
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| container_title | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences |
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| creator | Takagi, H Onodera, H Yun, L Yasuhara, K Koujitani, T Mitsumori, K Hirose, M |
| description | A 13-week subchronic oral toxicity study of ammonium sulfate was performed in both sexes of F344 rats by feeding them a CRF-1 powder diet containing concentrations of 0%, 0.38%, 0.75%, 1.5%, and 3.0% of the substance. Rats were randomly divided into 5 groups each consisting of 10 males and 10 females. Male animals in the 3% group exhibited diarrhea during the administration period. No changes indicating obvious ammonium sulfate toxicity were observed in the body weights, organ weights, hematological, serum biochemical, or histopathological examinations. Based on these results, the NOEL (no-observed-effect level) of ammonium sulfate for F344 rats was judged to be 1.5% in males (886 mg/kg/day) and 3% in females (1975 mg/kg/day), and the MTD (maximally tolerated dose) for 2-year carcinogenicity studies in F344 rats was concluded to be 3.0% or more in the diet. |
| format | Article |
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Rats were randomly divided into 5 groups each consisting of 10 males and 10 females. Male animals in the 3% group exhibited diarrhea during the administration period. No changes indicating obvious ammonium sulfate toxicity were observed in the body weights, organ weights, hematological, serum biochemical, or histopathological examinations. Based on these results, the NOEL (no-observed-effect level) of ammonium sulfate for F344 rats was judged to be 1.5% in males (886 mg/kg/day) and 3% in females (1975 mg/kg/day), and the MTD (maximally tolerated dose) for 2-year carcinogenicity studies in F344 rats was concluded to be 3.0% or more in the diet.</description><identifier>ISSN: 1343-4292</identifier><identifier>PMID: 10859942</identifier><language>jpn</language><publisher>Japan</publisher><subject>Ammonium Sulfate - administration & dosage ; Ammonium Sulfate - toxicity ; Animals ; Blood - drug effects ; Body Weight - drug effects ; Female ; Food Additives - administration & dosage ; Food Additives - toxicity ; Male ; No-Observed-Adverse-Effect Level ; Organ Size - drug effects ; Rats ; Rats, Inbred F344 ; Time Factors</subject><ispartof>Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1999 (117), p.108</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10859942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takagi, H</creatorcontrib><creatorcontrib>Onodera, H</creatorcontrib><creatorcontrib>Yun, L</creatorcontrib><creatorcontrib>Yasuhara, K</creatorcontrib><creatorcontrib>Koujitani, T</creatorcontrib><creatorcontrib>Mitsumori, K</creatorcontrib><creatorcontrib>Hirose, M</creatorcontrib><title>13-week subchronic oral toxicity study of ammonium sulfate in rats</title><title>Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences</title><addtitle>Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku</addtitle><description>A 13-week subchronic oral toxicity study of ammonium sulfate was performed in both sexes of F344 rats by feeding them a CRF-1 powder diet containing concentrations of 0%, 0.38%, 0.75%, 1.5%, and 3.0% of the substance. Rats were randomly divided into 5 groups each consisting of 10 males and 10 females. Male animals in the 3% group exhibited diarrhea during the administration period. No changes indicating obvious ammonium sulfate toxicity were observed in the body weights, organ weights, hematological, serum biochemical, or histopathological examinations. 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| identifier | ISSN: 1343-4292 |
| ispartof | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1999 (117), p.108 |
| issn | 1343-4292 |
| language | jpn |
| recordid | cdi_pubmed_primary_10859942 |
| source | MEDLINE; Freely Accessible Japanese Titles |
| subjects | Ammonium Sulfate - administration & dosage Ammonium Sulfate - toxicity Animals Blood - drug effects Body Weight - drug effects Female Food Additives - administration & dosage Food Additives - toxicity Male No-Observed-Adverse-Effect Level Organ Size - drug effects Rats Rats, Inbred F344 Time Factors |
| title | 13-week subchronic oral toxicity study of ammonium sulfate in rats |
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