Multiple agents potentiate alpha1-adrenoceptor-induced conduction depression in canine cardiac purkinje fibers

Halothane more so than isoflurane potentiates an alpha1-adrenoceptor (alpha1-AR)-mediated action of epinephrine that abnormally slows conduction in Purkinje fibers and may facilitate reentrant arrhythmias. This adverse drug interaction was further evaluated by examining conduction responses to epine...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2000-06, Vol.92 (6), p.1713
Hauptverfasser:	Kulier, A H, Turner, L A, Vodanovic, S, Contney, S, Lathrop, D A, Bosnjak, Z J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adrenergic alpha-Agonists - adverse effects Adrenergic alpha-Agonists - pharmacology Anesthetics - adverse effects Anesthetics - pharmacology Animals Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - physiopathology Dogs Drug Synergism Epinephrine - adverse effects Epinephrine - pharmacology Etomidate - adverse effects Etomidate - pharmacology Fatty Acids - metabolism Halothane - adverse effects Halothane - pharmacology Heart - innervation In Vitro Techniques Lidocaine - adverse effects Lidocaine - pharmacology Neural Conduction - drug effects Neural Conduction - physiology Octanols - adverse effects Octanols - pharmacology Palmitoylcarnitine - pharmacology Propofol - adverse effects Propofol - pharmacology Purkinje Fibers - drug effects Purkinje Fibers - physiology Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - physiology Thiopental - adverse effects Thiopental - pharmacology Verapamil - adverse effects Verapamil - pharmacology
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