Evaluation of the Therapeutic Effect of Transcatheter Arterial Embolization for Hepatocellular Carcinoma
Transcatheter arterial embolization (TAE) has been widely performed for patients with hepatocellular carcinoma (HCC). However, the method of evaluating the therapeutic effect of TAE has not been established. We examined the rate of necrotic area to whole tumor (TN) by CT, the tumor regression rate (...
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| Veröffentlicht in: | Oncology 2000-01, Vol.58 (4), p.293-299 |
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| creator | Okusaka, Takuji Okada, Shuichi Ueno, Hideki Ikeda, Masafumi Yoshimori, Masayoshi Shimada, Kazuaki Yamamoto, Junji Kosuge, Tomoo Yamasaki, Susumu Iwata, Ryoko Furukawa, Hiroyoshi Moriyama, Noriyuki Sakamoto, Michiie Hirohashi, Setsuo |
| description | Transcatheter arterial embolization (TAE) has been widely performed for patients with hepatocellular carcinoma (HCC). However, the method of evaluating the therapeutic effect of TAE has not been established. We examined the rate of necrotic area to whole tumor (TN) by CT, the tumor regression rate (TR) and the reduction rate in serum α-fetoprotein (AFP) levels in patients with HCC who received hepatic resection within 3 months after TAE. In the evaluation of TN, the lipiodol accumulation in tumor was regarded as being necrotic. Rates of necrotic area, which were also examined pathologically (PN) in resected tumors, were compared with TN, TR and AFP reduction rates, respectively. Eighty-eight patients were enrolled in this study, and there was a significant positive correlation between TN and PN (r = 0.80, p < 0.001). Although TR significantly correlated to PN (p = 0.001), the correlation coefficient between them was low (r = 0.34). The correlation coefficients between AFP reduction rate and PN was 0.76 (p < 0.001) in 26 patients (30%) with an AFP level ≥200 ng/ml before TAE. The evaluation method using lipiodol accumulation in CT is the most useful for assessing the therapeutic effect of TAE, particularly when a sufficiently long interval exists between TAE and the evaluation, because of the highest correlation coefficient between TN and PN, and the availability of TN for all patients. The reduction rate in serum AFP levels was also useful in patients with AFP levels >200 ng/ml before treatment. |
| doi_str_mv | 10.1159/000012115 |
| format | Article |
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However, the method of evaluating the therapeutic effect of TAE has not been established. We examined the rate of necrotic area to whole tumor (TN) by CT, the tumor regression rate (TR) and the reduction rate in serum α-fetoprotein (AFP) levels in patients with HCC who received hepatic resection within 3 months after TAE. In the evaluation of TN, the lipiodol accumulation in tumor was regarded as being necrotic. Rates of necrotic area, which were also examined pathologically (PN) in resected tumors, were compared with TN, TR and AFP reduction rates, respectively. Eighty-eight patients were enrolled in this study, and there was a significant positive correlation between TN and PN (r = 0.80, p < 0.001). Although TR significantly correlated to PN (p = 0.001), the correlation coefficient between them was low (r = 0.34). The correlation coefficients between AFP reduction rate and PN was 0.76 (p < 0.001) in 26 patients (30%) with an AFP level ≥200 ng/ml before TAE. The evaluation method using lipiodol accumulation in CT is the most useful for assessing the therapeutic effect of TAE, particularly when a sufficiently long interval exists between TAE and the evaluation, because of the highest correlation coefficient between TN and PN, and the availability of TN for all patients. The reduction rate in serum AFP levels was also useful in patients with AFP levels >200 ng/ml before treatment.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000012115</identifier><identifier>PMID: 10838494</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; alpha-Fetoproteins - metabolism ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - therapy ; Clinical Study ; Embolization, Therapeutic - methods ; Female ; Hepatic Artery ; Humans ; Infusions, Intra-Arterial ; Iodized Oil ; Liver Neoplasms - blood ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Necrosis ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Oncology, 2000-01, Vol.58 (4), p.293-299</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright (c) 2000 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-9e510221f2368743faf36e9dd502229fe556562a2b7abf3438ab1b4c78879d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10838494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okusaka, Takuji</creatorcontrib><creatorcontrib>Okada, Shuichi</creatorcontrib><creatorcontrib>Ueno, Hideki</creatorcontrib><creatorcontrib>Ikeda, Masafumi</creatorcontrib><creatorcontrib>Yoshimori, Masayoshi</creatorcontrib><creatorcontrib>Shimada, Kazuaki</creatorcontrib><creatorcontrib>Yamamoto, Junji</creatorcontrib><creatorcontrib>Kosuge, Tomoo</creatorcontrib><creatorcontrib>Yamasaki, Susumu</creatorcontrib><creatorcontrib>Iwata, Ryoko</creatorcontrib><creatorcontrib>Furukawa, Hiroyoshi</creatorcontrib><creatorcontrib>Moriyama, Noriyuki</creatorcontrib><creatorcontrib>Sakamoto, Michiie</creatorcontrib><creatorcontrib>Hirohashi, Setsuo</creatorcontrib><title>Evaluation of the Therapeutic Effect of Transcatheter Arterial Embolization for Hepatocellular Carcinoma</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Transcatheter arterial embolization (TAE) has been widely performed for patients with hepatocellular carcinoma (HCC). However, the method of evaluating the therapeutic effect of TAE has not been established. We examined the rate of necrotic area to whole tumor (TN) by CT, the tumor regression rate (TR) and the reduction rate in serum α-fetoprotein (AFP) levels in patients with HCC who received hepatic resection within 3 months after TAE. In the evaluation of TN, the lipiodol accumulation in tumor was regarded as being necrotic. Rates of necrotic area, which were also examined pathologically (PN) in resected tumors, were compared with TN, TR and AFP reduction rates, respectively. Eighty-eight patients were enrolled in this study, and there was a significant positive correlation between TN and PN (r = 0.80, p < 0.001). Although TR significantly correlated to PN (p = 0.001), the correlation coefficient between them was low (r = 0.34). The correlation coefficients between AFP reduction rate and PN was 0.76 (p < 0.001) in 26 patients (30%) with an AFP level ≥200 ng/ml before TAE. The evaluation method using lipiodol accumulation in CT is the most useful for assessing the therapeutic effect of TAE, particularly when a sufficiently long interval exists between TAE and the evaluation, because of the highest correlation coefficient between TN and PN, and the availability of TN for all patients. The reduction rate in serum AFP levels was also useful in patients with AFP levels >200 ng/ml before treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Clinical Study</subject><subject>Embolization, Therapeutic - methods</subject><subject>Female</subject><subject>Hepatic Artery</subject><subject>Humans</subject><subject>Infusions, Intra-Arterial</subject><subject>Iodized Oil</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkEtLxDAUhYMozji6cC1IcSG4qObV13Io9QEDs3D24bZNnI5tU5NW0F9vxg6jiHeRe0k-zrk5CJ0TfEtIkNxhV4S68QBNCafMx5TRQzTFmGGfcsIn6MTajaOigIfHaEJwzGKe8ClaZ-9QD9BXuvW08vq19FZraaCTQ18VXqaULPrty8pAawtwQC-NNzfurKD2sibXdfU5CihtvEfZQa8LWddDDcZLwRRVqxs4RUcKaivPdn2Gnu-zVfroL5YPT-l84Reckt5PZEAwpURRFsYRZwoUC2VSloG7pYmSQRAGIQWaR5ArxlkMOcl5EcVxlJRshq5H1c7ot0HaXjSV3S4DrdSDFZELyX2cOfDqD7jRg2ndZoJSHEdRiEMH3YxQYbS1RirRmaoB8yEIFtvkxT55x17uBIe8keUvcoz6x_EVzIs0e2CZLr4VRFcqB138C40eXy-pkdo</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Okusaka, Takuji</creator><creator>Okada, Shuichi</creator><creator>Ueno, Hideki</creator><creator>Ikeda, Masafumi</creator><creator>Yoshimori, Masayoshi</creator><creator>Shimada, Kazuaki</creator><creator>Yamamoto, Junji</creator><creator>Kosuge, Tomoo</creator><creator>Yamasaki, Susumu</creator><creator>Iwata, Ryoko</creator><creator>Furukawa, Hiroyoshi</creator><creator>Moriyama, Noriyuki</creator><creator>Sakamoto, Michiie</creator><creator>Hirohashi, Setsuo</creator><general>S. 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Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okusaka, Takuji</au><au>Okada, Shuichi</au><au>Ueno, Hideki</au><au>Ikeda, Masafumi</au><au>Yoshimori, Masayoshi</au><au>Shimada, Kazuaki</au><au>Yamamoto, Junji</au><au>Kosuge, Tomoo</au><au>Yamasaki, Susumu</au><au>Iwata, Ryoko</au><au>Furukawa, Hiroyoshi</au><au>Moriyama, Noriyuki</au><au>Sakamoto, Michiie</au><au>Hirohashi, Setsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Therapeutic Effect of Transcatheter Arterial Embolization for Hepatocellular Carcinoma</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>58</volume><issue>4</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Transcatheter arterial embolization (TAE) has been widely performed for patients with hepatocellular carcinoma (HCC). However, the method of evaluating the therapeutic effect of TAE has not been established. We examined the rate of necrotic area to whole tumor (TN) by CT, the tumor regression rate (TR) and the reduction rate in serum α-fetoprotein (AFP) levels in patients with HCC who received hepatic resection within 3 months after TAE. In the evaluation of TN, the lipiodol accumulation in tumor was regarded as being necrotic. Rates of necrotic area, which were also examined pathologically (PN) in resected tumors, were compared with TN, TR and AFP reduction rates, respectively. Eighty-eight patients were enrolled in this study, and there was a significant positive correlation between TN and PN (r = 0.80, p < 0.001). Although TR significantly correlated to PN (p = 0.001), the correlation coefficient between them was low (r = 0.34). The correlation coefficients between AFP reduction rate and PN was 0.76 (p < 0.001) in 26 patients (30%) with an AFP level ≥200 ng/ml before TAE. The evaluation method using lipiodol accumulation in CT is the most useful for assessing the therapeutic effect of TAE, particularly when a sufficiently long interval exists between TAE and the evaluation, because of the highest correlation coefficient between TN and PN, and the availability of TN for all patients. The reduction rate in serum AFP levels was also useful in patients with AFP levels >200 ng/ml before treatment.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>10838494</pmid><doi>10.1159/000012115</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged alpha-Fetoproteins - metabolism Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - therapy Clinical Study Embolization, Therapeutic - methods Female Hepatic Artery Humans Infusions, Intra-Arterial Iodized Oil Liver Neoplasms - blood Liver Neoplasms - diagnostic imaging Liver Neoplasms - therapy Male Middle Aged Necrosis Tomography, X-Ray Computed Treatment Outcome |
| title | Evaluation of the Therapeutic Effect of Transcatheter Arterial Embolization for Hepatocellular Carcinoma |
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