Receptor recognition by gp130 cytokines
Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both...
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| Veröffentlicht in: | The EMBO journal 2000-06, Vol.19 (11), p.2399-2411 |
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| container_title | The EMBO journal |
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| creator | Bravo, Jerónimo Heath, John K. |
| description | Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three‐dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective. |
| doi_str_mv | 10.1093/emboj/19.11.2399 |
| format | Article |
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Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three‐dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.</description><identifier>ISSN: 0261-4189</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1093/emboj/19.11.2399</identifier><identifier>PMID: 10835339</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Antigens, CD - metabolism ; Cytokine Receptor gp130 ; cytokines ; Cytokines - chemistry ; Cytokines - metabolism ; Dimerization ; Drug Design ; Epitopes - chemistry ; gp130 ; Growth Inhibitors - chemistry ; Human Growth Hormone - chemistry ; Human Growth Hormone - metabolism ; Humans ; Interleukin-6 - chemistry ; Leukemia Inhibitory Factor ; Ligands ; Lymphokines - chemistry ; Membrane Glycoproteins - metabolism ; Models, Molecular ; Multigene Family ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; receptor recognition epitopes ; receptor signalling complexes ; Receptors, Cytokine - metabolism ; Receptors, Somatotropin - chemistry ; Receptors, Somatotropin - metabolism ; Signal Transduction - physiology ; Structure-Activity Relationship</subject><ispartof>The EMBO journal, 2000-06, Vol.19 (11), p.2399-2411</ispartof><rights>Copyright © 2000 European Molecular Biology Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1093%2Femboj%2F19.11.2399$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1093%2Femboj%2F19.11.2399$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27933,27934,45583,45584,46418,46842</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10835339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bravo, Jerónimo</creatorcontrib><creatorcontrib>Heath, John K.</creatorcontrib><title>Receptor recognition by gp130 cytokines</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><description>Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three‐dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.</description><subject>Antigens, CD - metabolism</subject><subject>Cytokine Receptor gp130</subject><subject>cytokines</subject><subject>Cytokines - chemistry</subject><subject>Cytokines - metabolism</subject><subject>Dimerization</subject><subject>Drug Design</subject><subject>Epitopes - chemistry</subject><subject>gp130</subject><subject>Growth Inhibitors - chemistry</subject><subject>Human Growth Hormone - chemistry</subject><subject>Human Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Interleukin-6 - chemistry</subject><subject>Leukemia Inhibitory Factor</subject><subject>Ligands</subject><subject>Lymphokines - chemistry</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Models, Molecular</subject><subject>Multigene Family</subject><subject>Mutagenesis, Site-Directed</subject><subject>Protein Binding</subject><subject>Protein Conformation</subject><subject>Protein Structure, Tertiary</subject><subject>receptor recognition epitopes</subject><subject>receptor signalling complexes</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Receptors, Somatotropin - chemistry</subject><subject>Receptors, Somatotropin - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Structure-Activity Relationship</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQhhdRbK3evSi5eUq7k8lmZ4_a1mqpCqLobcnHbkk_kpCkaP69rdHqaWCe9xmGl7Fz4H3gCgdmHeWLAag-QN9DpQ5YF_yAux6X4pB1uReA6wOpDjupqgXnXJCEY9YBTigQVZddPZvYFHVeOqWJ83mW1mmeOVHjzAtA7sRNnS_TzFSn7MiGq8qc_cwee70dvwzv3NnT5H54PXNTBClcP7CRJ4nC2CYxWQ8oigiTCKzlJHxSRoaB4jEFHqD1fTRJst1SbIQ0hBZ77LK9W2yitUl0UabrsGz078fbgGoDH-nKNP-43jWivxvRoDSA3jWixw83UykU8kBs3YvWzcJ6U5q9_MfdlqdVbT73OCyXOpAohX57nOiZN6V3GklN-AWmTmyW</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Bravo, Jerónimo</creator><creator>Heath, John K.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000601</creationdate><title>Receptor recognition by gp130 cytokines</title><author>Bravo, Jerónimo ; Heath, John K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3175-46fb2788acfdc8f218bb83db1ff085489e7a690c86213f443edd4898ce57e83f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antigens, CD - metabolism</topic><topic>Cytokine Receptor gp130</topic><topic>cytokines</topic><topic>Cytokines - chemistry</topic><topic>Cytokines - metabolism</topic><topic>Dimerization</topic><topic>Drug Design</topic><topic>Epitopes - chemistry</topic><topic>gp130</topic><topic>Growth Inhibitors - chemistry</topic><topic>Human Growth Hormone - chemistry</topic><topic>Human Growth Hormone - metabolism</topic><topic>Humans</topic><topic>Interleukin-6 - chemistry</topic><topic>Leukemia Inhibitory Factor</topic><topic>Ligands</topic><topic>Lymphokines - chemistry</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Models, Molecular</topic><topic>Multigene Family</topic><topic>Mutagenesis, Site-Directed</topic><topic>Protein Binding</topic><topic>Protein Conformation</topic><topic>Protein Structure, Tertiary</topic><topic>receptor recognition epitopes</topic><topic>receptor signalling complexes</topic><topic>Receptors, Cytokine - metabolism</topic><topic>Receptors, Somatotropin - chemistry</topic><topic>Receptors, Somatotropin - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bravo, Jerónimo</creatorcontrib><creatorcontrib>Heath, John K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bravo, Jerónimo</au><au>Heath, John K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Receptor recognition by gp130 cytokines</atitle><jtitle>The EMBO journal</jtitle><addtitle>EMBO J</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>19</volume><issue>11</issue><spage>2399</spage><epage>2411</epage><pages>2399-2411</pages><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three‐dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10835339</pmid><doi>10.1093/emboj/19.11.2399</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0261-4189 |
| ispartof | The EMBO journal, 2000-06, Vol.19 (11), p.2399-2411 |
| issn | 0261-4189 1460-2075 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antigens, CD - metabolism Cytokine Receptor gp130 cytokines Cytokines - chemistry Cytokines - metabolism Dimerization Drug Design Epitopes - chemistry gp130 Growth Inhibitors - chemistry Human Growth Hormone - chemistry Human Growth Hormone - metabolism Humans Interleukin-6 - chemistry Leukemia Inhibitory Factor Ligands Lymphokines - chemistry Membrane Glycoproteins - metabolism Models, Molecular Multigene Family Mutagenesis, Site-Directed Protein Binding Protein Conformation Protein Structure, Tertiary receptor recognition epitopes receptor signalling complexes Receptors, Cytokine - metabolism Receptors, Somatotropin - chemistry Receptors, Somatotropin - metabolism Signal Transduction - physiology Structure-Activity Relationship |
| title | Receptor recognition by gp130 cytokines |
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