Pro-sterol carrier protein-2: role of the N-terminal presequence in structure, function, and peroxisomal targeting

Although the 20-amino acid presequence present in 15-kDa pro-sterol carrier protein-2 (pro-SCP-2, the precursor of the mature 13-kDa SCP-2) alters the function of SCP-2 in lipid metabolism, the molecular basis for this effect is unresolved. The presequence dramatically altered SCP-2 structure as det...

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Veröffentlicht in:	The Journal of biological chemistry 2000-08, Vol.275 (33), p.25547
Hauptverfasser:	Schroeder, F, Frolov, A, Starodub, O, Atshaves, B B, Russell, W, Petrescu, A, Huang, H, Gallegos, A M, McIntosh, A, Tahotna, D, Russell, D H, Billheimer, J T, Baum, C L, Kier, A B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters Blotting, Western Carboxypeptidases - metabolism Carboxypeptidases A Carrier Proteins - chemistry Carrier Proteins - physiology Cell Line Cell Membrane - metabolism Cholesterol - metabolism Circular Dichroism DNA, Complementary - metabolism Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Fatty Acids - metabolism Fluorescent Antibody Technique Fluorescent Antibody Technique, Indirect Guanidine - pharmacology Humans Immunoblotting Kinetics Ligands Membrane Proteins - metabolism Microscopy, Confocal Peroxisomes - metabolism Plant Proteins Protein Folding Protein Precursors - chemistry Protein Precursors - physiology Protein Structure, Secondary Protein Structure, Tertiary Rats Recombinant Proteins - chemistry Recombinant Proteins - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Structure-Activity Relationship Transfection Tumor Cells, Cultured
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