Chloroquine: A Multipotent Inhibitor of Human Platelets in Vitro

Chloroquine inhibited human platelet aggregation in vitro both at receptor- and nonreceptor-operated stimuli. The inhibition was dose-dependent, recorded on isolated platelets as well as in platelet-rich plasma, and followed the rank order of stimuli: adrenaline (second phase)>phorbol 12-myristat...

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Veröffentlicht in:	Thrombosis research 2000-06, Vol.98 (5), p.411-421
Hauptverfasser:	NOSAL, R, JANCINOVA, V, DANIHELOVA, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aggregation Arachidonate cascade Arachidonic Acid - metabolism Biological and medical sciences Blood Platelets - drug effects Blood. Blood coagulation. Reticuloendothelial system Calcimycin - pharmacology Chloroquine Chloroquine - pharmacology Dose-Response Relationship, Drug Epinephrine - pharmacology Histamine Humans Malondialdehyde - metabolism Medical sciences Middle Aged Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelets Serotonin Tetradecanoylphorbol Acetate - pharmacology Thrombin - pharmacology Thromboxane B2 - biosynthesis Time Factors Tritium
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