Direct Activation of Capsaicin Receptors by Products of Lipoxygenases: Endogenous Capsaicin-Like Substances

Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons, and thereby produces severe pain. A nonselective cation channel activated by capsaicin has been identified in sensory neurons and a cDNA encoding the channel has been cloned recently. However, an endogenous a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.6155-6160
Hauptverfasser:	Hwang, Sun Wook, Cho, Hawon, Kwak, Jiyeon, Lee, Soon-Youl, Kang, Chang-Joong, Jung, Jooyoung, Cho, Soohyun, Min, Kyung Hoon, Suh, Young-Ger, Kim, Donghee, Oh, Uhtaek
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological Sciences capsaicin Capsaicin - analogs & derivatives Capsaicin - chemistry Capsaicin - pharmacology capsaicin receptors Capsicum Cell Line Cells, Cultured Dinoprostone - chemistry Dinoprostone - pharmacology Eicosanoids Eicosanoids - chemistry Eicosanoids - pharmacology Enzymes Ganglia, Spinal - cytology Humans hydroxyeicosatetraenoic acids Hydroxyeicosatetraenoic Acids - chemistry Hydroxyeicosatetraenoic Acids - pharmacology Inflammation Ion Channel Gating - drug effects leukotriene B4 Leukotriene B4 - pharmacology Leukotrienes - chemistry Leukotrienes - pharmacology Ligands Lipid Peroxides - chemistry Lipid Peroxides - pharmacology Lipids Lipoxygenase - metabolism Molecular Structure Neurology Neurons Neurons, Afferent - drug effects Neuroscience Pain Prostaglandin D2 - chemistry Prostaglandin D2 - pharmacology Prostaglandin H2 Prostaglandins H - chemistry Prostaglandins H - pharmacology Rats Receptors Receptors, Drug - drug effects Receptors, Drug - physiology Sensory neurons Spinal ganglia Structure-Activity Relationship TRPV cation channels
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