Synaptophysin Regulates Clathrin-Independent Endocytosis of Synaptic Vesicles

The GTPase dynamin I is required for synaptic vesicle (SV) endocytosis. Our observation that dynamin binds to the SV protein synaptophysin in a Ca2+-dependent fashion suggested the possibility that a dynamin/synaptophysin complex functions in SV recycling. In this paper we show that disruption of th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (11), p.6120-6125
Hauptverfasser:	Daly, Christopher, Sugimori, Mutsuyuki, Moreira, Jorge E., Ziff, Edward B., Llinas, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potentials Animals Biological Sciences Calcium - physiology Cell membranes Clathrin - physiology Decapodiformes dynamin Dynamin I Dynamins Endocytosis Endocytosis - physiology GTP Phosphohydrolases - physiology Macromolecular Substances Membrane Fusion Nerve Tissue Proteins - physiology Neurology Neuroscience Peptides Proteins Radio transmitters Recombinant Fusion Proteins - physiology Recycling Squid Stellate Ganglion - cytology Synapses Synaptic Transmission - physiology Synaptic Vesicles - physiology Synaptophysin - physiology Transmitters
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