Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats

The rat mammary adenocarcinoma 13762A is weakly immunogenic in syngeneic hosts. Transplantation immunity is not developed after injection of irradiated tumor cells. Two cell types were isolated from the tumor: one grew slowly forming solid implants; the second grew rapidly in ascites form, even in a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of immunology (1950) 1975-11, Vol.115 (5), p.1269
Hauptverfasser: Fortner, G. William, Kuperman, Oded, Lucas, Zoltan J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 5
container_start_page 1269
container_title The Journal of immunology (1950)
container_volume 115
creator Fortner, G. William
Kuperman, Oded
Lucas, Zoltan J
description The rat mammary adenocarcinoma 13762A is weakly immunogenic in syngeneic hosts. Transplantation immunity is not developed after injection of irradiated tumor cells. Two cell types were isolated from the tumor: one grew slowly forming solid implants; the second grew rapidly in ascites form, even in allogeneic hosts. Spleen cells cytotoxic for a tissue culture derivative of the tumor were produced in animals after injection of either cell type indicating a common antigen. The kinetics of tumor growth and production of cytotoxic spleen cells were compared in syngeneic and allogeneic animals. In vivo rejection of the tumor in allogeneic hosts did not correlate with the in vitro assay of spleen lymphocyte cytotoxicity. Futhermore, the cytotoxic response of spleen cells from syngeneic tumor-bearing hosts parallels that found in allogeneic hosts.
format Article
fullrecord <record><control><sourceid>pubmed_highw</sourceid><recordid>TN_cdi_pubmed_primary_1080776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1080776</sourcerecordid><originalsourceid>FETCH-LOGICAL-h153t-d9f26c35b4a29f228cfed687caf2f973cd8363ba02d292aad18d941d7e912c053</originalsourceid><addsrcrecordid>eNpNUNFKwzAUDaLMOf0E4b75VEnSNW19G0XnUBHmfC53SbpGmmQ0HXU_47fasQk-nXM4h3O494yMWZLQSAgqzsmYUs4jlor0klyF8EUpFZRPR2TEaEbTVIzJz8LandOw1GHrXdDQeUD42LuNdtpIeENrsd3DTGnnJbbSOG_xARb3UHi7xdYE78BX8GKc7owMB77aWd9CoZsG5q3vuxrQKSj2ne_891D6NxbAuH9bh9CsafxJLrEL1-SiwibomxNOyOfT46p4jl7f54ti9hrVLIm7SOUVFzJO1lPkA-WZrLQSWSqx4lWexlJlsYjXSLniOUdULFP5lKlU54xLmsQTcnvs3e7WVqty25rD2eXpT4N_d_Rrs6l70-oyWGyaIc3Kvu8ZS8qkZFzk8S_miHUn</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Fortner, G. William ; Kuperman, Oded ; Lucas, Zoltan J</creator><creatorcontrib>Fortner, G. William ; Kuperman, Oded ; Lucas, Zoltan J</creatorcontrib><description>The rat mammary adenocarcinoma 13762A is weakly immunogenic in syngeneic hosts. Transplantation immunity is not developed after injection of irradiated tumor cells. Two cell types were isolated from the tumor: one grew slowly forming solid implants; the second grew rapidly in ascites form, even in allogeneic hosts. Spleen cells cytotoxic for a tissue culture derivative of the tumor were produced in animals after injection of either cell type indicating a common antigen. The kinetics of tumor growth and production of cytotoxic spleen cells were compared in syngeneic and allogeneic animals. In vivo rejection of the tumor in allogeneic hosts did not correlate with the in vitro assay of spleen lymphocyte cytotoxicity. Futhermore, the cytotoxic response of spleen cells from syngeneic tumor-bearing hosts parallels that found in allogeneic hosts.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>PMID: 1080776</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Adenocarcinoma - immunology ; Adenocarcinoma - metabolism ; Agglutination Tests ; Animals ; Ascitic Fluid - cytology ; Ascitic Fluid - immunology ; Concanavalin A - pharmacology ; Cytotoxicity Tests, Immunologic ; Female ; Kinetics ; Mammary Neoplasms, Experimental - immunology ; Mammary Neoplasms, Experimental - metabolism ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Spleen - immunology ; Transplantation, Homologous ; Transplantation, Isogeneic</subject><ispartof>The Journal of immunology (1950), 1975-11, Vol.115 (5), p.1269</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1080776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fortner, G. William</creatorcontrib><creatorcontrib>Kuperman, Oded</creatorcontrib><creatorcontrib>Lucas, Zoltan J</creatorcontrib><title>Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The rat mammary adenocarcinoma 13762A is weakly immunogenic in syngeneic hosts. Transplantation immunity is not developed after injection of irradiated tumor cells. Two cell types were isolated from the tumor: one grew slowly forming solid implants; the second grew rapidly in ascites form, even in allogeneic hosts. Spleen cells cytotoxic for a tissue culture derivative of the tumor were produced in animals after injection of either cell type indicating a common antigen. The kinetics of tumor growth and production of cytotoxic spleen cells were compared in syngeneic and allogeneic animals. In vivo rejection of the tumor in allogeneic hosts did not correlate with the in vitro assay of spleen lymphocyte cytotoxicity. Futhermore, the cytotoxic response of spleen cells from syngeneic tumor-bearing hosts parallels that found in allogeneic hosts.</description><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - metabolism</subject><subject>Agglutination Tests</subject><subject>Animals</subject><subject>Ascitic Fluid - cytology</subject><subject>Ascitic Fluid - immunology</subject><subject>Concanavalin A - pharmacology</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Female</subject><subject>Kinetics</subject><subject>Mammary Neoplasms, Experimental - immunology</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Spleen - immunology</subject><subject>Transplantation, Homologous</subject><subject>Transplantation, Isogeneic</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUNFKwzAUDaLMOf0E4b75VEnSNW19G0XnUBHmfC53SbpGmmQ0HXU_47fasQk-nXM4h3O494yMWZLQSAgqzsmYUs4jlor0klyF8EUpFZRPR2TEaEbTVIzJz8LandOw1GHrXdDQeUD42LuNdtpIeENrsd3DTGnnJbbSOG_xARb3UHi7xdYE78BX8GKc7owMB77aWd9CoZsG5q3vuxrQKSj2ne_891D6NxbAuH9bh9CsafxJLrEL1-SiwibomxNOyOfT46p4jl7f54ti9hrVLIm7SOUVFzJO1lPkA-WZrLQSWSqx4lWexlJlsYjXSLniOUdULFP5lKlU54xLmsQTcnvs3e7WVqty25rD2eXpT4N_d_Rrs6l70-oyWGyaIc3Kvu8ZS8qkZFzk8S_miHUn</recordid><startdate>197511</startdate><enddate>197511</enddate><creator>Fortner, G. William</creator><creator>Kuperman, Oded</creator><creator>Lucas, Zoltan J</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197511</creationdate><title>Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats</title><author>Fortner, G. William ; Kuperman, Oded ; Lucas, Zoltan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h153t-d9f26c35b4a29f228cfed687caf2f973cd8363ba02d292aad18d941d7e912c053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - metabolism</topic><topic>Agglutination Tests</topic><topic>Animals</topic><topic>Ascitic Fluid - cytology</topic><topic>Ascitic Fluid - immunology</topic><topic>Concanavalin A - pharmacology</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Female</topic><topic>Kinetics</topic><topic>Mammary Neoplasms, Experimental - immunology</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><topic>Spleen - immunology</topic><topic>Transplantation, Homologous</topic><topic>Transplantation, Isogeneic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fortner, G. William</creatorcontrib><creatorcontrib>Kuperman, Oded</creatorcontrib><creatorcontrib>Lucas, Zoltan J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fortner, G. William</au><au>Kuperman, Oded</au><au>Lucas, Zoltan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1975-11</date><risdate>1975</risdate><volume>115</volume><issue>5</issue><spage>1269</spage><pages>1269-</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The rat mammary adenocarcinoma 13762A is weakly immunogenic in syngeneic hosts. Transplantation immunity is not developed after injection of irradiated tumor cells. Two cell types were isolated from the tumor: one grew slowly forming solid implants; the second grew rapidly in ascites form, even in allogeneic hosts. Spleen cells cytotoxic for a tissue culture derivative of the tumor were produced in animals after injection of either cell type indicating a common antigen. The kinetics of tumor growth and production of cytotoxic spleen cells were compared in syngeneic and allogeneic animals. In vivo rejection of the tumor in allogeneic hosts did not correlate with the in vitro assay of spleen lymphocyte cytotoxicity. Futhermore, the cytotoxic response of spleen cells from syngeneic tumor-bearing hosts parallels that found in allogeneic hosts.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>1080776</pmid></addata></record>
fulltext fulltext
identifier ISSN: 0022-1767
ispartof The Journal of immunology (1950), 1975-11, Vol.115 (5), p.1269
issn 0022-1767
1550-6606
language eng
recordid cdi_pubmed_primary_1080776
source MEDLINE; Alma/SFX Local Collection
subjects Adenocarcinoma - immunology
Adenocarcinoma - metabolism
Agglutination Tests
Animals
Ascitic Fluid - cytology
Ascitic Fluid - immunology
Concanavalin A - pharmacology
Cytotoxicity Tests, Immunologic
Female
Kinetics
Mammary Neoplasms, Experimental - immunology
Mammary Neoplasms, Experimental - metabolism
Rats
Rats, Inbred F344
Rats, Inbred Lew
Spleen - immunology
Transplantation, Homologous
Transplantation, Isogeneic
title Immune Response to a Syngeneic Mammary Adenocarcinoma: I. Comparison of Kinetics of Tumor Cell Growth and Cytotoxic Responses in Syngeneic and Allogeneic Rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A55%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20Response%20to%20a%20Syngeneic%20Mammary%20Adenocarcinoma:%20I.%20Comparison%20of%20Kinetics%20of%20Tumor%20Cell%20Growth%20and%20Cytotoxic%20Responses%20in%20Syngeneic%20and%20Allogeneic%20Rats&rft.jtitle=The%20Journal%20of%20immunology%20(1950)&rft.au=Fortner,%20G.%20William&rft.date=1975-11&rft.volume=115&rft.issue=5&rft.spage=1269&rft.pages=1269-&rft.issn=0022-1767&rft.eissn=1550-6606&rft_id=info:doi/&rft_dat=%3Cpubmed_highw%3E1080776%3C/pubmed_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/1080776&rfr_iscdi=true