Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area

We investigated if taurine, an endogenous GABA analog, could mimic both hyperpolarizing and depolarizing GABA(A)-mediated responses as well as pre- and postsynaptic GABA(B)-mediated actions in the CA1 region of rat hippocampal slices. Taurine (10 mM) perfusion induced changes in membrane potential a...

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Veröffentlicht in:	Brain research 2000-05, Vol.864 (2), p.298
Hauptverfasser:	del Olmo, N, Bustamante, J, del Río, R M, Solís, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Animals Baclofen - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female GABA Agonists - pharmacology GABA Antagonists - pharmacology gamma-Aminobutyric Acid - pharmacology Hippocampus - chemistry Hippocampus - drug effects Hippocampus - physiology Organ Culture Techniques Picrotoxin - pharmacology Pyramidal Cells - chemistry Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Receptors, GABA-B - physiology Synapses - chemistry Synapses - drug effects Synapses - physiology Taurine - pharmacology Tetrodotoxin - pharmacology
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